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Nuclear-Overhauser-enhanced MR imaging of 31P-containing metabolites: multipoint-Dixon vs. frequency-selective excitation

The purpose of this study is to develop nuclear-Overhauser-enhanced (NOE) [1H]-31P magnetic resonance imaging (MRI) based on 3D fully-balanced steady-state free precession (fbSSFP). Therefore, two implementations of a 3D fbSSFP sequence are compared using frequency-selective excitation (FreqSel) and...

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Hauptverfasser: Rink, Kristian (VerfasserIn) , Berger, Moritz C. (VerfasserIn) , Korzowski, Andreas (VerfasserIn) , Breithaupt, Mathies (VerfasserIn) , Biller, Armin (VerfasserIn) , Bachert, Peter (VerfasserIn) , Nagel, Armin Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [2015]
In: Magnetic resonance imaging
Year: 2015, Jahrgang: 33, Heft: 10, Pages: 1281-1289
ISSN:1873-5894
DOI:10.1016/j.mri.2015.07.017
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.mri.2015.07.017
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0730725X15001939
Volltext
Verfasserangaben:Kristian Rink, Moritz C. Berger, Andreas Korzowski, Mathies Breithaupt, Armin Biller, Peter Bachert, Armin M. Nagel
Beschreibung
Zusammenfassung:The purpose of this study is to develop nuclear-Overhauser-enhanced (NOE) [1H]-31P magnetic resonance imaging (MRI) based on 3D fully-balanced steady-state free precession (fbSSFP). Therefore, two implementations of a 3D fbSSFP sequence are compared using frequency-selective excitation (FreqSel) and multipoint-Dixon (MP-Dixon). 31P-containing model solutions and four healthy volunteers were examined at field strengths of B0=3T and 7T. Maps of the distribution of phosphocreatine (PCr), inorganic phosphate (Pi), and adenosine 5´-triphosphate (ATP) in the human calf were obtained with an isotropic resolution of 1.5cm (1.0cm) in an acquisition time of 5min (10min). NOE-pulses had the highest impact on the PCr acquisitions enhancing the signal up to (82 ± 13) % at 3T and up to (37 ± 9) % at 7T. An estimation of the level of PCr in muscle tissue from [1H]-31P MRI data yielded a mean value of (33 ± 8) mM. In conclusion, direct [1H]-31P imaging using FreqSel as well as MP-Dixon is possible in clinically feasible acquisition times. FreqSel should be preferred for measurements where only a single metabolite resonance is considered. MP-Dixon performs better in terms of SNR if a larger spectral width is of interest.
Beschreibung:Die 31 im Titel ist hochgestellt
Gesehen am 25.06.2020
Beschreibung:Online Resource
ISSN:1873-5894
DOI:10.1016/j.mri.2015.07.017

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