Nuclear-Overhauser-enhanced MR imaging of 31P-containing metabolites: multipoint-Dixon vs. frequency-selective excitation
The purpose of this study is to develop nuclear-Overhauser-enhanced (NOE) [1H]-31P magnetic resonance imaging (MRI) based on 3D fully-balanced steady-state free precession (fbSSFP). Therefore, two implementations of a 3D fbSSFP sequence are compared using frequency-selective excitation (FreqSel) and...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[2015]
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| In: |
Magnetic resonance imaging
Year: 2015, Jahrgang: 33, Heft: 10, Pages: 1281-1289 |
| ISSN: | 1873-5894 |
| DOI: | 10.1016/j.mri.2015.07.017 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.mri.2015.07.017 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0730725X15001939 |
| Verfasserangaben: | Kristian Rink, Moritz C. Berger, Andreas Korzowski, Mathies Breithaupt, Armin Biller, Peter Bachert, Armin M. Nagel |
MARC
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| 245 | 1 | 0 | |a Nuclear-Overhauser-enhanced MR imaging of 31P-containing metabolites |b multipoint-Dixon vs. frequency-selective excitation |c Kristian Rink, Moritz C. Berger, Andreas Korzowski, Mathies Breithaupt, Armin Biller, Peter Bachert, Armin M. Nagel |
| 246 | 3 | 3 | |a Nuclear-Overhauser-enhanced MR imaging of 31 P-containing metabolites |
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| 520 | |a The purpose of this study is to develop nuclear-Overhauser-enhanced (NOE) [1H]-31P magnetic resonance imaging (MRI) based on 3D fully-balanced steady-state free precession (fbSSFP). Therefore, two implementations of a 3D fbSSFP sequence are compared using frequency-selective excitation (FreqSel) and multipoint-Dixon (MP-Dixon). 31P-containing model solutions and four healthy volunteers were examined at field strengths of B0=3T and 7T. Maps of the distribution of phosphocreatine (PCr), inorganic phosphate (Pi), and adenosine 5´-triphosphate (ATP) in the human calf were obtained with an isotropic resolution of 1.5cm (1.0cm) in an acquisition time of 5min (10min). NOE-pulses had the highest impact on the PCr acquisitions enhancing the signal up to (82 ± 13) % at 3T and up to (37 ± 9) % at 7T. An estimation of the level of PCr in muscle tissue from [1H]-31P MRI data yielded a mean value of (33 ± 8) mM. In conclusion, direct [1H]-31P imaging using FreqSel as well as MP-Dixon is possible in clinically feasible acquisition times. FreqSel should be preferred for measurements where only a single metabolite resonance is considered. MP-Dixon performs better in terms of SNR if a larger spectral width is of interest. | ||
| 650 | 4 | |a Dixon | |
| 650 | 4 | |a High-energy phosphate metabolism | |
| 650 | 4 | |a Nuclear Overhauser effect | |
| 650 | 4 | |a P MRI | |
| 650 | 4 | |a Steady-state free precession (SSFP) | |
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| 700 | 1 | |a Korzowski, Andreas |e VerfasserIn |0 (DE-588)1073894142 |0 (DE-627)829772901 |0 (DE-576)435387081 |4 aut | |
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