The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity
Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also p...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 August 2015
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| In: |
Frontiers in cell and developmental biology
Year: 2015, Jahrgang: 3, Pages: 1-13 |
| ISSN: | 2296-634X |
| DOI: | 10.3389/fcell.2015.00048 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fcell.2015.00048 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528279/ 
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| Verfasserangaben: | Stephanie Wallner, Sebastian Peters, Claudia Pitzer, Herbert Resch, Ulrich Bogdahn and Armin Schneider |
| Zusammenfassung: | Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor. |
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| Beschreibung: | Gesehen am 26.06.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 2296-634X |
| DOI: | 10.3389/fcell.2015.00048 |