Nuclear overhauser enhancement imaging of glioblastoma at 7 tesla: region specific correlation with apparent diffusion coefficient and histology
Objective To explore the correlation between Nuclear Overhauser Enhancement (NOE)-mediated signals and tumor cellularity in glioblastoma utilizing the apparent diffusion coefficient (ADC) and cell density from histologic specimens. NOE is one type of chemical exchange saturation transfer (CEST) that...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 19, 2015
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| In: |
PLOS ONE
Year: 2015, Jahrgang: 10, Heft: 3 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0121220 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0121220 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121220 
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| Verfasserangaben: | Daniel Paech, Sina Burth, Johannes Windschuh, Jan-Eric Meissner, Moritz Zaiss, Oliver Eidel, Philipp Kickingereder, Martha Nowosielski, Benedikt Wiestler, Felix Sahm, Ralf Omar Floca, Jan-Oliver Neumann, Wolfgang Wick, Sabine Heiland, Martin Bendszus, Heinz-Peter Schlemmer, Mark Edward Ladd, Peter Bachert, Alexander Radbruch |
MARC
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| 245 | 1 | 0 | |a Nuclear overhauser enhancement imaging of glioblastoma at 7 tesla |b region specific correlation with apparent diffusion coefficient and histology |c Daniel Paech, Sina Burth, Johannes Windschuh, Jan-Eric Meissner, Moritz Zaiss, Oliver Eidel, Philipp Kickingereder, Martha Nowosielski, Benedikt Wiestler, Felix Sahm, Ralf Omar Floca, Jan-Oliver Neumann, Wolfgang Wick, Sabine Heiland, Martin Bendszus, Heinz-Peter Schlemmer, Mark Edward Ladd, Peter Bachert, Alexander Radbruch |
| 246 | 3 | 3 | |a Nuclear overhauser enhancement imaging of glioblastoma at seven tesla |
| 264 | 1 | |c March 19, 2015 | |
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| 520 | |a Objective To explore the correlation between Nuclear Overhauser Enhancement (NOE)-mediated signals and tumor cellularity in glioblastoma utilizing the apparent diffusion coefficient (ADC) and cell density from histologic specimens. NOE is one type of chemical exchange saturation transfer (CEST) that originates from mobile macromolecules such as proteins and might be associated with tumor cellularity via altered protein synthesis in proliferating cells. Patients and Methods For 15 patients with newly diagnosed glioblastoma, NOE-mediated CEST-contrast was acquired at 7 Tesla (asymmetric magnetization transfer ratio (MTRasym) at 3.3ppm, B1 = 0.7 μT). Contrast enhanced T1 (CE-T1), T2 and diffusion-weighted MRI (DWI) were acquired at 3 Tesla and coregistered. The T2 edema and the CE-T1 tumor were segmented. ADC and MTRasym values within both regions of interest were correlated voxelwise yielding the correlation coefficient rSpearman (rSp). In three patients who underwent stereotactic biopsy, cell density of 12 specimens per patient was correlated with corresponding MTRasym and ADC values of the biopsy site. Results Eight of 15 patients showed a weak or moderate positive correlation of MTRasym and ADC within the T2 edema (0.16≤rSp≤0.53, p<0.05). Seven correlations were statistically insignificant (p>0.05, n = 4) or yielded rSp≈0 (p<0.05, n = 3). No trend towards a correlation between MTRasym and ADC was found in CE-T1 tumor (-0.31<rSp<0.28, p<0.05, n = 9; p>0.05, n = 6). The biopsy-analysis within CE-T1 tumor revealed a strong positive correlation between tumor cellularity and MTRasym values in two of the three patients (rSppatient3 = 0.69 and rSppatient15 = 0.87, p<0.05), while the correlation of ADC and cellularity was heterogeneous (rSppatient3 = 0.545 (p = 0.067), rSppatient4 = -0.021 (p = 0.948), rSppatient15 = -0.755 (p = 0.005)). Discussion NOE-imaging is a new contrast promising insight into pathophysiologic processes in glioblastoma regarding cell density and protein content, setting itself apart from DWI. Future studies might be based on the assumption that NOE-mediated CEST visualizes cellularity more accurately than ADC, especially in the CE-T1 tumor region. | ||
| 650 | 4 | |a Adenocarcinomas | |
| 650 | 4 | |a Biopsy | |
| 650 | 4 | |a Diffusion weighted imaging | |
| 650 | 4 | |a Edema | |
| 650 | 4 | |a Glioblastoma multiforme | |
| 650 | 4 | |a Linear regression analysis | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Necrosis | |
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