Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age
Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
06 October 2015
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| In: |
Immunity & ageing
Year: 2015, Volume: 12, Issue: 1, Pages: 1-5 |
| ISSN: | 1742-4933 |
| DOI: | 10.1186/s12979-015-0043-y |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12979-015-0043-y |
| Author Notes: | Xiaoyu Wu, Maani Hakimi, Markus Wortmann, Jian Zhang, Dittmar Böckler, Susanne Dihlmann |
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| 520 | |a Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating intracellular multi-protein complexes. We thus investigated gene expression of inflammasome components in PBMC of 77 vascular patients (age 22-82) in association with age. | ||
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