Ursodeoxycholyl lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD
Background Hepatic fat accumulation with disturbed lipid homoeostasis is a hallmark of nonalcoholic fatty liver disease (NAFLD). The bile acid phospholipid conjugate Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) is a novel anti-inflammatory agent with hepatoprotective effects in murine hig...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 June 2015
|
| In: |
European journal of clinical investigation
Year: 2015, Volume: 45, Issue: 9, Pages: 925-931 |
| ISSN: | 1365-2362 |
| DOI: | 10.1111/eci.12486 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/eci.12486 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.12486 
|
| Author Notes: | Anita Pathil, Gerhard Liebisch, Jürgen G. Okun, Walee Chamulitrat, Gerd Schmitz and Wolfgang Stremmel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1703013441 | ||
| 003 | DE-627 | ||
| 005 | 20230427154001.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200701s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/eci.12486 |2 doi | |
| 035 | |a (DE-627)1703013441 | ||
| 035 | |a (DE-599)KXP1703013441 | ||
| 035 | |a (OCoLC)1341342139 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Pathil-Warth, Anita |d 1981- |e VerfasserIn |0 (DE-588)132644304 |0 (DE-627)524715890 |0 (DE-576)260118915 |4 aut | |
| 245 | 1 | 0 | |a Ursodeoxycholyl lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD |c Anita Pathil, Gerhard Liebisch, Jürgen G. Okun, Walee Chamulitrat, Gerd Schmitz and Wolfgang Stremmel |
| 264 | 1 | |c 24 June 2015 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.07.2020 | ||
| 520 | |a Background Hepatic fat accumulation with disturbed lipid homoeostasis is a hallmark of nonalcoholic fatty liver disease (NAFLD). The bile acid phospholipid conjugate Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) is a novel anti-inflammatory agent with hepatoprotective effects in murine high-fat-diet (HFD)-induced NAFLD. The aim of this work was to study changes in the hepatic lipidome due to UDCA-LPE. Materials and methods High fat diet mouse model, mass spectometry, RT-PCR. Results Hepatic lipid extracts of HFD mice were analysed by mass spectrometry. The results determined higher levels of total, saturated, mono- and diunsaturated fatty acids (FA) in HFD mice, which were decreased by UDCA-LPE predominantly by the reducing the most abundant FA species palmitic acid and oleic acid. Unlike other FA species, levels of long-chain polyunsaturated fatty acids (LCPUFA), which are composed of arachidonic acid (ARA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were increased in HFD mice upon UDCA-LPE treatment, mainly due to elevated hepatic ARA pools. Analysis of hepatic phospholipids species showed a decrease in total phosphatidylcholine (PC), especially monounsaturated PC (PUFA-PC) levels in HFD mice. Loss of total PC was reversed due to UDCA-LPE by increasing hepatic PUFA-PC pools. Gene expression analysis showed that UDCA-LPE upregulated PPARα, a key transcriptional regulator of fatty acid oxidation, as well as downstream target genes CPT1α and AOX, which are crucially involved in mitochondrial and peroxisomal fatty acid oxidation. Conclusion UDCA-LPE modulates defective fatty acid metabolism during experimental NAFLD thereby restoring altered lipid profiles in addition to its pronounced anti-inflammatory effects. Thus, UDCA-LPE may be a promising drug candidate for the management of NAFLD. | ||
| 650 | 4 | |a Fatty acid composition | |
| 650 | 4 | |a non-alcoholic fatty liver disease | |
| 650 | 4 | |a UDCA-LPE | |
| 700 | 1 | |a Liebisch, Gerhard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Okun, Jürgen G. |d 1968- |e VerfasserIn |0 (DE-588)121578232 |0 (DE-627)705551415 |0 (DE-576)292781296 |4 aut | |
| 700 | 1 | |a Chamulitrat, Walee |d 1959- |e VerfasserIn |0 (DE-588)1037336828 |0 (DE-627)755493915 |0 (DE-576)39134479X |4 aut | |
| 700 | 1 | |a Schmitz, Gerd |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stremmel, Wolfgang |d 1952- |e VerfasserIn |0 (DE-588)142773638 |0 (DE-627)640118747 |0 (DE-576)33331560X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of clinical investigation |d Oxford [u.a.] : Wiley-Blackwell, 1970 |g 45(2015), 9, Seite 925-931 |h Online-Ressource |w (DE-627)320441423 |w (DE-600)2004971-7 |w (DE-576)091142695 |x 1365-2362 |7 nnas |a Ursodeoxycholyl lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD |
| 773 | 1 | 8 | |g volume:45 |g year:2015 |g number:9 |g pages:925-931 |g extent:7 |a Ursodeoxycholyl lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD |
| 856 | 4 | 0 | |u https://doi.org/10.1111/eci.12486 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.12486 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200701 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 142773638 |a Stremmel, Wolfgang |m 142773638:Stremmel, Wolfgang |d 910000 |d 910100 |e 910000PS142773638 |e 910100PS142773638 |k 0/910000/ |k 1/910000/910100/ |p 6 |y j | ||
| 998 | |g 1037336828 |a Chamulitrat, Walee |m 1037336828:Chamulitrat, Walee |d 910000 |d 910100 |e 910000PC1037336828 |e 910100PC1037336828 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 121578232 |a Okun, Jürgen G. |m 121578232:Okun, Jürgen G. |d 910000 |d 910500 |e 910000PO121578232 |e 910500PO121578232 |k 0/910000/ |k 1/910000/910500/ |p 3 | ||
| 998 | |g 132644304 |a Pathil-Warth, Anita |m 132644304:Pathil-Warth, Anita |d 910000 |d 910100 |e 910000PP132644304 |e 910100PP132644304 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1703013441 |e 3692619200 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Anita","role":"aut","display":"Pathil-Warth, Anita","family":"Pathil-Warth"},{"role":"aut","given":"Gerhard","family":"Liebisch","display":"Liebisch, Gerhard"},{"given":"Jürgen G.","role":"aut","display":"Okun, Jürgen G.","family":"Okun"},{"family":"Chamulitrat","display":"Chamulitrat, Walee","role":"aut","given":"Walee"},{"display":"Schmitz, Gerd","family":"Schmitz","given":"Gerd","role":"aut"},{"family":"Stremmel","display":"Stremmel, Wolfgang","role":"aut","given":"Wolfgang"}],"physDesc":[{"extent":"7 S."}],"relHost":[{"disp":"Ursodeoxycholyl lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLDEuropean journal of clinical investigation","origin":[{"publisher":"Wiley-Blackwell ; Blackwell Science ; Blackwell","dateIssuedDisp":"1970-","dateIssuedKey":"1970","publisherPlace":"Oxford [u.a.] ; Oxford [u.a.] ; Oxford [u.a.]"}],"part":{"issue":"9","pages":"925-931","volume":"45","text":"45(2015), 9, Seite 925-931","year":"2015","extent":"7"},"recId":"320441423","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"subtitle":"the journal of the European Society for Clinical Investigation","title":"European journal of clinical investigation","title_sort":"European journal of clinical investigation"}],"id":{"eki":["320441423"],"doi":["10.1111/(ISSN)1365-2362"],"issn":["1365-2362"],"zdb":["2004971-7"]},"pubHistory":["1.1970/71 -"]}],"title":[{"title_sort":"Ursodeoxycholyl lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD","title":"Ursodeoxycholyl lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1703013441"],"doi":["10.1111/eci.12486"]},"origin":[{"dateIssuedDisp":"24 June 2015","dateIssuedKey":"2015"}],"recId":"1703013441","note":["Gesehen am 01.07.2020"],"language":["eng"],"name":{"displayForm":["Anita Pathil, Gerhard Liebisch, Jürgen G. Okun, Walee Chamulitrat, Gerd Schmitz and Wolfgang Stremmel"]}} | ||
| SRT | |a PATHILWARTURSODEOXYC2420 | ||