[Eta]-secretase processing of APP inhibits neuronal activity in the hippocampus

A new pathway for the processing of β-amyloid precursor protein (APP) is described in which η-secretase activity, in part mediated by the MT5-MMP metalloproteinase, cleaves APP, and further processing by ADAM10 and BACE1 generates proteolytic fragments capable of inhibiting long-term potentiation in...

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Main Authors:	Willem, Michael (Author) , Tahirovic, Sabina (Author) , Busche, Marc Aurel (Author) , Ovsepian, Saak V. (Author) , Chafai, Magda (Author) , Kootar, Scherazad (Author) , Hornburg, Daniel (Author) , Evans, Lewis D. B. (Author) , Moore, Steven (Author) , Daria, Anna (Author) , Hampel, Heike (Author) , Müller, Veronika (Author) , Giudici, Camilla (Author) , Nuscher, Brigitte (Author) , Wenninger-Weinzierl, Andrea (Author) , Kremmer, Elisabeth (Author) , Heneka, Michael T. (Author) , Thal, Dietmar R. (Author) , Giedraitis, Vilmantas (Author) , Lannfelt, Lars (Author) , Müller, Ulrike C. (Author) , Livesey, Frederick J. (Author) , Meissner, Felix (Author) , Herms, Jochen (Author) , Konnerth, Arthur (Author) , Marie, Hélène (Author) , Haass, Christian (Author)
Format:	Article (Journal)
Language:	English
Published:	31 August 2015
In:	Nature Year: 2015, Volume: 526, Issue: 7573, Pages: 443-447
ISSN:	1476-4687
DOI:	10.1038/nature14864
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature14864 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature14864
Author Notes:	Michael Willem, Sabina Tahirovic, Marc Aurel Busche, Saak V. Ovsepian, Magda Chafai, Scherazad Kootar, Daniel Hornburg, Lewis D. B. Evans, Steven Moore, Anna Daria, Heike Hampel, Veronika Müller, Camilla Giudici, Brigitte Nuscher, Andrea Wenninger-Weinzierl, Elisabeth Kremmer, Michael T. Heneka, Dietmar R. Thal, Vilmantas Giedraitis, Lars Lannfelt, Ulrike Müller, Frederick J. Livesey, Felix Meissner, Jochen Herms, Arthur Konnerth, Hélène Marie & Christian Haass