Closing the gap: a roadmap to single-cell regulatory genomics
Studying the spatiotemporal control of gene regulatory networks at the single-cell level is still a challenge, yet it is key to understanding the mechanisms driving cellular identity. In their recent study, Aerts and colleagues (Gonzalez-Blas et al, 2020) develop a new strategy to spatially map and...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 2020
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| In: |
Molecular systems biology
Year: 2020, Volume: 16, Issue: 5 |
| ISSN: | 1744-4292 |
| Online Access: | Verlag, Volltext: https://www.embopress.org/doi/epdf/10.15252/msb.20209497
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| Author Notes: | Julie Carnesecchi & Ingrid Lohmann |
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| 520 | |a Studying the spatiotemporal control of gene regulatory networks at the single-cell level is still a challenge, yet it is key to understanding the mechanisms driving cellular identity. In their recent study, Aerts and colleagues (Gonzalez-Blas et al, 2020) develop a new strategy to spatially map and integrate single-cell transcriptome and epigenome profiles in the Drosophila eye-antennal disc and to deduce in each cell precise enhancer-to-gene activity relationships. This opens a new era in the transcriptional regulation field, as it allows extracting from each of the thousands of cells forming a tissue the critical features driving their identity, from enhancer sequences to transcription factors to gene regulatory networks. | ||
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