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Transient RNA-DNA hybrids are required for efficient double-strand break repair

RNA-DNA hybrids are a major internal cause of DNA damage within cells, and their degradation by RNase H enzymes is important for maintaining genomic stability. Here, we identified an unexpected role for RNA-DNA hybrids and RNase H enzymes in DNA repair. Using a site-specific DNA double-strand break...

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Hauptverfasser: Ohle, Corina (VerfasserIn) , Tesorero, Rafael (VerfasserIn) , Schermann, Géza (VerfasserIn) , Dobrev, Nikolay (VerfasserIn) , Sinning, Irmgard (VerfasserIn) , Fischer, Tamás (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 27 October 2016
In: Cell
Year: 2016, Jahrgang: 167, Heft: 4, Pages: 1001-1013, e1-e7
ISSN:1097-4172
DOI:10.1016/j.cell.2016.10.001
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2016.10.001
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0092867416313824
Volltext
Verfasserangaben:Corina Ohle, Rafael Tesorero, Géza Schermann, Nikolay Dobrev, Irmgard Sinning, Tamás Fischer

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