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Influence of age on resection of colorectal liver metastases

Background and Objectives Only limited data exist investigating the outcome of patients older than 75 years after resection of colorectal liver metastases (CLM). Therefore, the present study aims to evaluate clinical and oncological outcome of elderly patients. Methods A cohort of 405 patients was d...

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Main Authors: Schmidt, Thomas (Author) , Strowitzki, Moritz (Author) , Reißfelder, Christoph (Author) , Rahbari, Nuh Nabi (Author) , Nienhüser, Henrik (Author) , Bruckner, Thomas (Author) , Rahäuser, Christoph (Author) , Keppler, Ulrich (Author) , Schneider, Martin (Author) , Büchler, Markus W. (Author) , Ulrich, Alexis (Author)
Format: Article (Journal)
Language:English
Published: 16 January 2015
In: Journal of surgical oncology
Year: 2015, Volume: 111, Issue: 6, Pages: 729-739
ISSN:1096-9098
DOI:10.1002/jso.23872
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/jso.23872
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.23872
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Author Notes:Thomas Schmidt, MD, PhD, Moritz J. Strowitzki, MD, Christoph Reissfelder, MD, Nuh N. Rahbari, MD, Henrik Nienhueser, MD, Thomas Bruckner, PhD, Christoph Rahäuser, cand. med. dent., Ulrich Keppler, MD, Martin Schneider, MD, Markus W. Büchler, MD, and Alexis Ulrich, MD
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Summary:Background and Objectives Only limited data exist investigating the outcome of patients older than 75 years after resection of colorectal liver metastases (CLM). Therefore, the present study aims to evaluate clinical and oncological outcome of elderly patients. Methods A cohort of 405 patients was divided into three age-groups: (1) <65 years; (2) 65-75 years; and (3) >75 years of age. Patients' data were prospectively collected and retrospectively analyzed. We performed survival analysis and added age-correction. Univariate and multivariate analysis was performed to determine independent prognostic risk factors. Results The 5-year survival rate of the >75 years age-group was distinctly decreased, compared to the other age-groups. After age-correction, the 5-year survival rates and the survival curves increased to the greatest extent in patients older than 75 years. The MSKCC score proved to be a sufficient independent prognostic factor in the total patient cohort, patients <65 years and patients 65-75 years. In patients older than 75 years, only localization of the primary tumors was a significant prognostic factor for overall survival. Conclusions Patients' age is no reason to deny surgical treatment of CLM. Prognostic factors, such as MSKCC score, are not sufficient predictors of survival in patients older than 75 years. J. Surg. Oncol. 2015 111:729-739. © 2015 Wiley Periodicals, Inc.
Item Description:Gesehen am 06.07.2020
Physical Description:Online Resource
ISSN:1096-9098
DOI:10.1002/jso.23872

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