Cover Image

A coding-independent function of an alternative Ube3a transcript during neuronal development

This work shows a nocoding function of Ube3a1 RNA, an alternative transcript encoded by the Angelman syndrome gene Ube3a. Valluy et al. observe that Ube3a1 RNA competes with dendritic mRNAs for microRNAs, thereby regulating dendrite arborization and spine maturation of hippocampal neurons. These fin...

Full description

Saved in:
Bibliographic Details
Main Authors: Valluy, Jeremy Matthias (Author) , Bicker, Silvia (Author) , Aksoy Aksel, Ayla (Author) , Lackinger, Martin (Author) , Sumer, Simon (Author) , Fiore, Roberto (Author) , Wüst, Tatjana (Author) , Seffer, Dominik (Author) , Metge, Franziska (Author) , Dieterich, Christoph (Author) , Wöhr, Markus (Author) , Schwarting, Rainer (Author) , Schratt, Gerhard (Author)
Format: Article (Journal)
Language:English
Published: 13 April 2015
In: Nature neuroscience
Year: 2015, Volume: 18, Issue: 5, Pages: 666-673
ISSN:1546-1726
DOI:10.1038/nn.3996
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nn.3996
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nn.3996
Get full text
Author Notes:Jeremy Valluy, Silvia Bicker, Ayla Aksoy-Aksel, Martin Lackinger, Simon Sumer, Roberto Fiore, Tatjana Wüst, Dominik Seffer, Franziska Metge, Christoph Dieterich, Markus Wöhr, Rainer Schwarting, Gerhard Schratt
Description
Summary:This work shows a nocoding function of Ube3a1 RNA, an alternative transcript encoded by the Angelman syndrome gene Ube3a. Valluy et al. observe that Ube3a1 RNA competes with dendritic mRNAs for microRNAs, thereby regulating dendrite arborization and spine maturation of hippocampal neurons. These findings suggest a function for competing endogenous RNAs in synaptic development.
Item Description:Gesehen am 07.07.2020
Physical Description:Online Resource
ISSN:1546-1726
DOI:10.1038/nn.3996

Similar Items