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Inflammatory profiling of early experimental necrotizing pancreatitis

Aims: Inflammatory mediators play a pivotal role in severe necrotizing pancreatitis (SNP). Therapeutic approaches aim at the early inflammatory liberation of cytokines to avoid systemic complications. The present study evaluates the kinetics of inflammatory mediator release in SNP. - Main methods: E...

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Hauptverfasser: Schneider, Lutz (VerfasserIn) , Jabrailova, Bahar (VerfasserIn) , Strobel, Oliver (VerfasserIn) , Hackert, Thilo (VerfasserIn) , Werner, Jens (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 21 February 2015
In: Life sciences
Year: 2015, Jahrgang: 126, Pages: 76-80
ISSN:1879-0631
DOI:10.1016/j.lfs.2015.01.029
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.lfs.2015.01.029
Volltext
Verfasserangaben:Lutz Schneider, Bahar Jabrailova, Oliver Strobel, Thilo Hackert, Jens Werner

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520 |a Aims: Inflammatory mediators play a pivotal role in severe necrotizing pancreatitis (SNP). Therapeutic approaches aim at the early inflammatory liberation of cytokines to avoid systemic complications. The present study evaluates the kinetics of inflammatory mediator release in SNP. - Main methods: Experimental SNP was induced in male Wistar rats using the GDOC model. The animals were allocated into seven groups (n = 6/group). In group 1, sample harvesting was performed after sham operation while in groups 2-7 this was performed 1 h, 2 h, 4 h, 6 h, 9 h, and 12 h after initiation of SNP, respectively. Inflammatory mediator release,morphologic injury, and tissue MPO concentrations were evaluated between 1 and 12 h after induction. - Key findings: Pancreatic injury showed a continuous increase over the observation period (p b 0.05, respectively). MPO levels in the pancreas and lungs increased until 12 h after induction (p b 0.05, respectively). Antiinflammatory IL-10 showed an early peak and the pro-inflammatory mediators TNFα and IL-1β peaked after 6 and 9 h, respectively (p b 0.05, respectively). HMGB1 levels constantly increased over time (p b 0.05, respectively). - Significance: The present study shows the release of relevant pro- and anti-inflammatory mediators in SNP for the first time in one single experimental setup. Inflammatory mediators peak within the first few hours after SNP induction. Consequently, the effect of therapeutic approaches on early changes in cytokine release should be evaluated later than 2 h after initiation. 
650 4 |a Acute pancreatitis 
650 4 |a Animals 
650 4 |a Cytokines 
650 4 |a Disease Models, Animal 
650 4 |a Experimental 
650 4 |a HMGB1 Protein 
650 4 |a Inflammation Mediators 
650 4 |a Interleukin-1beta 
650 4 |a Male 
650 4 |a Myeloperoxidase 
650 4 |a Necrotizing pancreatitis 
650 4 |a Pancreatitis, Acute Necrotizing 
650 4 |a Rats 
650 4 |a Rats, Wistar 
650 4 |a Severe pancreatitis 
650 4 |a Systemic complications 
650 4 |a Tumor Necrosis Factor-alpha 
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