Buchumschlag

Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer

Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Rosenberger, Ina (VerfasserIn) , Dimitrakopoulou-Strauss, Antonia (VerfasserIn) , Dobiasch, Sophie (VerfasserIn) , Weis, Christian (VerfasserIn) , Szanyi, Szilard (VerfasserIn) , Gil-Iceta, L. (VerfasserIn) , Alonso, E. (VerfasserIn) , González Esparza, M. (VerfasserIn) , Gómez-Vallejo, V. (VerfasserIn) , Szczupak, B. (VerfasserIn) , Plaza-García, S. (VerfasserIn) , Mirzaei, S. (VerfasserIn) , Israel, L. L. (VerfasserIn) , Bianchessi, S. (VerfasserIn) , Scanziani, E. (VerfasserIn) , Lellouche, J. -P. (VerfasserIn) , Knoll, P. (VerfasserIn) , Werner, Jens (VerfasserIn) , Felix, Klaus M. (VerfasserIn) , Grenacher, L. (VerfasserIn) , Reese, T. (VerfasserIn) , Kreuter, J. (VerfasserIn) , Jiménez-González, M. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 July 2015
In: Journal of controlled release
Year: 2015, Jahrgang: 214, Pages: 76-84
ISSN:1873-4995
DOI:10.1016/j.jconrel.2015.07.017
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jconrel.2015.07.017
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0168365915300304
Volltext
Verfasserangaben:I. Rosenberger, A. Strauss, S. Dobiasch, C. Weis, S. Szanyi, L. Gil-Iceta, E. Alonso, M. González Esparza, V. Gómez-Vallejo, B. Szczupak, S. Plaza-García, S. Mirzaei, L. L. Israel, S. Bianchessi, E. Scanziani, J. -P. Lellouche, P. Knoll, J. Werner, K. Felix, L. Grenacher, T. Reese, J. Kreuter, M. Jiménez-González
Beschreibung
Zusammenfassung:Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, γ-Fe2O3) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography-computer tomography (SPECT-CT), a handheld gamma camera, and magnetic resonance imaging (MRI).
Beschreibung:Gesehen am 08.07.2020
Beschreibung:Online Resource
ISSN:1873-4995
DOI:10.1016/j.jconrel.2015.07.017

Ähnliche Einträge