Browning of white adipose tissue uncouples glucose uptake from insulin signaling
Presence of thermogenically active adipose tissue in adult humans has been inversely associated with obesity and type 2 diabetes. While it had been shown that insulin is crucial for the development of classical brown fat, its role in development and function of inducible brown-in-white (brite) adipo...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 14, 2014
|
| In: |
PLOS ONE
Year: 2014, Volume: 9, Issue: 10 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0110428 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0110428 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110428 
|
| Author Notes: | Karin Mössenböck, Alexandros Vegiopoulos, Adam J. Rose, Tjeerd P. Sijmonsma, Stephan Herzig, Tobias Schafmeier |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1713946432 | ||
| 003 | DE-627 | ||
| 005 | 20220818143936.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200708s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0110428 |2 doi | |
| 035 | |a (DE-627)1713946432 | ||
| 035 | |a (DE-599)KXP1713946432 | ||
| 035 | |a (OCoLC)1341344859 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mössenböck, Karin |e VerfasserIn |0 (DE-588)1120624525 |0 (DE-627)873622405 |0 (DE-576)480459282 |4 aut | |
| 245 | 1 | 0 | |a Browning of white adipose tissue uncouples glucose uptake from insulin signaling |c Karin Mössenböck, Alexandros Vegiopoulos, Adam J. Rose, Tjeerd P. Sijmonsma, Stephan Herzig, Tobias Schafmeier |
| 264 | 1 | |c October 14, 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.07.2020 | ||
| 520 | |a Presence of thermogenically active adipose tissue in adult humans has been inversely associated with obesity and type 2 diabetes. While it had been shown that insulin is crucial for the development of classical brown fat, its role in development and function of inducible brown-in-white (brite) adipose tissue is less clear. Here we show that insulin deficiency impaired differentiation of brite adipocytes. However, adrenergic stimulation almost fully induced the thermogenic program under these settings. Although brite differentiation of adipocytes as well as browning of white adipose tissue entailed substantially elevated glucose uptake by adipose tissue, the capacity of insulin to stimulate glucose uptake surprisingly was not higher in the brite state. Notably, in line with the insulin-independent stimulation of glucose uptake, our data revealed that brite recruitment results in induction of solute carrier family 2 (GLUT-1) expression in adipocytes and inguinal WAT. These results for the first time demonstrate that insulin signaling is neither essential for brite recruitment, nor is it improved in cells or tissues upon browning. | ||
| 650 | 4 | |a Adipocyte differentiation | |
| 650 | 4 | |a Adipocytes | |
| 650 | 4 | |a Adipose tissue | |
| 650 | 4 | |a Brown adipose tissue | |
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Glucose | |
| 650 | 4 | |a Insulin | |
| 650 | 4 | |a Mouse models | |
| 700 | 1 | |a Vegiopoulos, Alexandros |e VerfasserIn |0 (DE-588)1203732104 |0 (DE-627)1688773711 |4 aut | |
| 700 | 1 | |a Rose, Adam J. |e VerfasserIn |0 (DE-588)1124103651 |0 (DE-627)877826994 |0 (DE-576)482304014 |4 aut | |
| 700 | 1 | |a Sijmonsma, Tjeerd P. |e VerfasserIn |0 (DE-588)1147590567 |0 (DE-627)1006339280 |0 (DE-576)495880736 |4 aut | |
| 700 | 1 | |a Herzig, Stephan |d 1969- |e VerfasserIn |0 (DE-588)12146623X |0 (DE-627)705470857 |0 (DE-576)292725949 |4 aut | |
| 700 | 1 | |a Schafmeier, Tobias |e VerfasserIn |0 (DE-588)1124111581 |0 (DE-627)877843759 |0 (DE-576)482320087 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 9(2014,10) Artikel-Nummer e110428, 11 Seiten |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a Browning of white adipose tissue uncouples glucose uptake from insulin signaling |
| 773 | 1 | 8 | |g volume:9 |g year:2014 |g number:10 |a Browning of white adipose tissue uncouples glucose uptake from insulin signaling |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pone.0110428 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110428 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200708 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 1124111581 |a Schafmeier, Tobias |m 1124111581:Schafmeier, Tobias |p 6 |y j | ||
| 998 | |g 12146623X |a Herzig, Stephan |m 12146623X:Herzig, Stephan |d 700000 |d 706000 |e 700000PH12146623X |e 706000PH12146623X |k 0/700000/ |k 1/700000/706000/ |p 5 | ||
| 998 | |g 1147590567 |a Sijmonsma, Tjeerd P. |m 1147590567:Sijmonsma, Tjeerd P. |p 4 | ||
| 998 | |g 1124103651 |a Rose, Adam J. |m 1124103651:Rose, Adam J. |d 140000 |e 140000PR1124103651 |k 0/140000/ |p 3 | ||
| 998 | |g 1203732104 |a Vegiopoulos, Alexandros |m 1203732104:Vegiopoulos, Alexandros |d 140000 |e 140000PV1203732104 |k 0/140000/ |p 2 | ||
| 998 | |g 1120624525 |a Mössenböck, Karin |m 1120624525:Mössenböck, Karin |d 700000 |d 706000 |e 700000PM1120624525 |e 706000PM1120624525 |k 0/700000/ |k 1/700000/706000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1713946432 |e 3711484425 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1713946432","title":[{"title":"Browning of white adipose tissue uncouples glucose uptake from insulin signaling","title_sort":"Browning of white adipose tissue uncouples glucose uptake from insulin signaling"}],"person":[{"family":"Mössenböck","role":"aut","given":"Karin","roleDisplay":"VerfasserIn","display":"Mössenböck, Karin"},{"family":"Vegiopoulos","role":"aut","roleDisplay":"VerfasserIn","given":"Alexandros","display":"Vegiopoulos, Alexandros"},{"given":"Adam J.","roleDisplay":"VerfasserIn","display":"Rose, Adam J.","family":"Rose","role":"aut"},{"role":"aut","family":"Sijmonsma","display":"Sijmonsma, Tjeerd P.","roleDisplay":"VerfasserIn","given":"Tjeerd P."},{"role":"aut","family":"Herzig","display":"Herzig, Stephan","roleDisplay":"VerfasserIn","given":"Stephan"},{"display":"Schafmeier, Tobias","roleDisplay":"VerfasserIn","given":"Tobias","role":"aut","family":"Schafmeier"}],"relHost":[{"recId":"523574592","id":{"issn":["1932-6203"],"eki":["523574592"],"zdb":["2267670-3"]},"language":["eng"],"disp":"Browning of white adipose tissue uncouples glucose uptake from insulin signalingPLOS ONE","title":[{"title":"PLOS ONE","title_sort":"PLOS ONE"}],"part":{"text":"9(2014,10) Artikel-Nummer e110428, 11 Seiten","volume":"9","year":"2014","issue":"10"},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"2006-","dateIssuedKey":"2006","publisherPlace":"San Francisco, California, US ; Lawrence, Kan.","publisher":"PLOS ; PLoS"}],"note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.2006 -"],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Public Library of Science","role":"isb"}],"name":{"displayForm":["Public Library of Science"]}}],"origin":[{"dateIssuedDisp":"October 14, 2014","dateIssuedKey":"2014"}],"note":["Gesehen am 08.07.2020"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1713946432"],"doi":["10.1371/journal.pone.0110428"]},"name":{"displayForm":["Karin Mössenböck, Alexandros Vegiopoulos, Adam J. Rose, Tjeerd P. Sijmonsma, Stephan Herzig, Tobias Schafmeier"]},"language":["eng"]} | ||
| SRT | |a MOESSENBOEBROWNINGOF1420 | ||