Synthesis and biological evaluation of 9-N-oxamyl sialosides as siglec-7 ligands
Siglecs (sialic acid recognizing immunoglobulin like lectins) are a family of lectins with specificity for sialic acid containing carbohydrates. Synthetic sialic acid derivatives with high affinity proved useful to unravel the biological role of the ligand binding domain, although many of their func...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 July 2015
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| In: |
Bioorganic & medicinal chemistry
Year: 2015, Jahrgang: 23, Heft: 17, Pages: 5915-5921 |
| ISSN: | 1464-3391 |
| DOI: | 10.1016/j.bmc.2015.06.069 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bmc.2015.06.069 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0968089615005635 
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| Verfasserangaben: | Horst Prescher, Stephan Gütgemann, Martin Frank, Elena Kuhfeldt, Carsten Watzl, Reinhard Brossmer |
MARC
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| 520 | |a Siglecs (sialic acid recognizing immunoglobulin like lectins) are a family of lectins with specificity for sialic acid containing carbohydrates. Synthetic sialic acid derivatives with high affinity proved useful to unravel the biological role of the ligand binding domain, although many of their functions in immunity remain unknown. Here we present design, synthesis, affinity evaluation and molecular modeling of novel 9-N-oxamoyl modified sialosides as Siglec-7 ligands. | ||
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