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Synthesis and biological evaluation of 9-N-oxamyl sialosides as siglec-7 ligands

Siglecs (sialic acid recognizing immunoglobulin like lectins) are a family of lectins with specificity for sialic acid containing carbohydrates. Synthetic sialic acid derivatives with high affinity proved useful to unravel the biological role of the ligand binding domain, although many of their func...

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Hauptverfasser: Prescher, Horst (VerfasserIn) , Gütgemann, Stephan (VerfasserIn) , Frank, Martin (VerfasserIn) , Kuhfeldt, Elena (VerfasserIn) , Watzl, Carsten (VerfasserIn) , Brossmer, Reinhard (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 7 July 2015
In: Bioorganic & medicinal chemistry
Year: 2015, Jahrgang: 23, Heft: 17, Pages: 5915-5921
ISSN:1464-3391
DOI:10.1016/j.bmc.2015.06.069
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bmc.2015.06.069
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0968089615005635
Volltext
Verfasserangaben:Horst Prescher, Stephan Gütgemann, Martin Frank, Elena Kuhfeldt, Carsten Watzl, Reinhard Brossmer
Beschreibung
Zusammenfassung:Siglecs (sialic acid recognizing immunoglobulin like lectins) are a family of lectins with specificity for sialic acid containing carbohydrates. Synthetic sialic acid derivatives with high affinity proved useful to unravel the biological role of the ligand binding domain, although many of their functions in immunity remain unknown. Here we present design, synthesis, affinity evaluation and molecular modeling of novel 9-N-oxamoyl modified sialosides as Siglec-7 ligands.
Beschreibung:Gesehen am 09.07.2020
Beschreibung:Online Resource
ISSN:1464-3391
DOI:10.1016/j.bmc.2015.06.069

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