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Synthesis and biological evaluation of 9-N-oxamyl sialosides as siglec-7 ligands

Siglecs (sialic acid recognizing immunoglobulin like lectins) are a family of lectins with specificity for sialic acid containing carbohydrates. Synthetic sialic acid derivatives with high affinity proved useful to unravel the biological role of the ligand binding domain, although many of their func...

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Bibliographic Details
Main Authors: Prescher, Horst (Author) , Gütgemann, Stephan (Author) , Frank, Martin (Author) , Kuhfeldt, Elena (Author) , Watzl, Carsten (Author) , Brossmer, Reinhard (Author)
Format: Article (Journal)
Language:English
Published: 7 July 2015
In: Bioorganic & medicinal chemistry
Year: 2015, Volume: 23, Issue: 17, Pages: 5915-5921
ISSN:1464-3391
DOI:10.1016/j.bmc.2015.06.069
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bmc.2015.06.069
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0968089615005635
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Author Notes:Horst Prescher, Stephan Gütgemann, Martin Frank, Elena Kuhfeldt, Carsten Watzl, Reinhard Brossmer
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Summary:Siglecs (sialic acid recognizing immunoglobulin like lectins) are a family of lectins with specificity for sialic acid containing carbohydrates. Synthetic sialic acid derivatives with high affinity proved useful to unravel the biological role of the ligand binding domain, although many of their functions in immunity remain unknown. Here we present design, synthesis, affinity evaluation and molecular modeling of novel 9-N-oxamoyl modified sialosides as Siglec-7 ligands.
Item Description:Gesehen am 09.07.2020
Physical Description:Online Resource
ISSN:1464-3391
DOI:10.1016/j.bmc.2015.06.069

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