Patient preferences in adjuvant and palliative treatment of advanced melanoma: a discrete choice experiment
Treatment paradigms for advanced melanoma have changed fundamentally over recent years. A discrete choice experiment was performed to explore patient preferences regarding outcome (overall response rate, 2-year survival rate, progression-free survival, time to response, type of adverse events, proba...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 February 2020
|
| In: |
Acta dermato-venereologica
Year: 2020, Jahrgang: 100, Heft: 3 |
| ISSN: | 1651-2057 |
| DOI: | 10.2340/00015555-3422 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2340/00015555-3422
|
| Verfasserangaben: | Juliane Weilandt, Katharina Diehl, Marthe-Lisa Schaarschmidt, Felix Kiecker, Bianca Sasama, Melanie Pronk, Jan Ohletz, Andreas Könnecke, Verena Müller, Jochen Utikal, Uwe Hillen, Wolfgang Harth and Wiebke K. Peitsch |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1724133446 | ||
| 003 | DE-627 | ||
| 005 | 20230426081758.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200709s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2340/00015555-3422 |2 doi | |
| 035 | |a (DE-627)1724133446 | ||
| 035 | |a (DE-599)KXP1724133446 | ||
| 035 | |a (OCoLC)1341345067 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Weilandt, Juliane |e VerfasserIn |0 (DE-588)1213487935 |0 (DE-627)1724137263 |4 aut | |
| 245 | 1 | 0 | |a Patient preferences in adjuvant and palliative treatment of advanced melanoma |b a discrete choice experiment |c Juliane Weilandt, Katharina Diehl, Marthe-Lisa Schaarschmidt, Felix Kiecker, Bianca Sasama, Melanie Pronk, Jan Ohletz, Andreas Könnecke, Verena Müller, Jochen Utikal, Uwe Hillen, Wolfgang Harth and Wiebke K. Peitsch |
| 264 | 1 | |c 14 February 2020 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 09.07.2020 | ||
| 520 | |a Treatment paradigms for advanced melanoma have changed fundamentally over recent years. A discrete choice experiment was performed to explore patient preferences regarding outcome (overall response rate, 2-year survival rate, progression-free survival, time to response, type of adverse events, probability of adverse event-related treatment discontinuation) and process attributes (frequency and route of administration, frequency of consultations) of modern treatments for melanoma. Mean preferences of 150 patients with melanoma stage IIC-IV were highest for overall response rate (relative importance score (RIS) 26.8) and 2-year survival (RIS 21.6), followed by type of adverse events (RIS 11.7) and probability of adverse event-related treatment discontinuation (RIS 9.2). Interest in overall response rate and 2-year survival declined with increasing age, whereas process attributes gained importance. Participants who had experienced treatment with immune checkpoint inhibitors valued overall response rate more highly and worried less about the type of adverse events. In conclusion, patients with advanced melanoma consider efficacy of treatment options most important, followed by safety, but preferences vary with individual and disease-related characteristics. | ||
| 650 | 4 | |a braf | |
| 650 | 4 | |a BRAF inhibitors | |
| 650 | 4 | |a cobimetinib | |
| 650 | 4 | |a conjoint analysis | |
| 650 | 4 | |a dabrafenib | |
| 650 | 4 | |a immune checkpoint inhibitors | |
| 650 | 4 | |a ipilimumab | |
| 650 | 4 | |a melanoma | |
| 650 | 4 | |a nivolumab | |
| 650 | 4 | |a patient preferences | |
| 650 | 4 | |a pembrolizumab | |
| 650 | 4 | |a stage-iii | |
| 650 | 4 | |a survival | |
| 650 | 4 | |a targeted therapy | |
| 650 | 4 | |a therapies | |
| 650 | 4 | |a vemurafenib | |
| 700 | 1 | |a Diehl, Katharina |d 1984- |e VerfasserIn |0 (DE-588)1028339259 |0 (DE-627)730593738 |0 (DE-576)375833587 |4 aut | |
| 700 | 1 | |a Schaarschmidt, Marthe-Lisa |d 1986- |e VerfasserIn |0 (DE-588)1033397377 |0 (DE-627)741158892 |0 (DE-576)380994593 |4 aut | |
| 700 | 1 | |a Kiecker, Felix |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sasama, Bianca |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pronk, Melanie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ohletz, Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Könnecke, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Müller, Verena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Utikal, Jochen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hillen, Uwe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Harth, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Peitsch, Wiebke K. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Acta dermato-venereologica |d Uppsala : Acta Dermato-Venereologica, 1921 |g 100(2020,3) Artikel-Nummer adv00083, 9 Seiten |h Online-Ressource |w (DE-627)302725431 |w (DE-600)1492617-9 |w (DE-576)081952848 |x 1651-2057 |7 nnas |a Patient preferences in adjuvant and palliative treatment of advanced melanoma a discrete choice experiment |
| 773 | 1 | 8 | |g volume:100 |g year:2020 |g number:3 |g extent:9 |a Patient preferences in adjuvant and palliative treatment of advanced melanoma a discrete choice experiment |
| 856 | 4 | 0 | |u https://doi.org/10.2340/00015555-3422 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200709 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1033397377 |a Schaarschmidt, Marthe-Lisa |m 1033397377:Schaarschmidt, Marthe-Lisa |d 60000 |d 61900 |e 60000PS1033397377 |e 61900PS1033397377 |k 0/60000/ |k 1/60000/61900/ |p 3 | ||
| 998 | |g 1028339259 |a Diehl, Katharina |m 1028339259:Diehl, Katharina |d 60000 |d 65300 |e 60000PD1028339259 |e 65300PD1028339259 |k 0/60000/ |k 1/60000/65300/ |p 2 | ||
| 999 | |a KXP-PPN1724133446 |e 372275559X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","display":"Weilandt, Juliane","roleDisplay":"VerfasserIn","given":"Juliane","family":"Weilandt"},{"display":"Diehl, Katharina","roleDisplay":"VerfasserIn","role":"aut","family":"Diehl","given":"Katharina"},{"roleDisplay":"VerfasserIn","display":"Schaarschmidt, Marthe-Lisa","role":"aut","family":"Schaarschmidt","given":"Marthe-Lisa"},{"display":"Kiecker, Felix","roleDisplay":"VerfasserIn","role":"aut","family":"Kiecker","given":"Felix"},{"given":"Bianca","family":"Sasama","role":"aut","display":"Sasama, Bianca","roleDisplay":"VerfasserIn"},{"family":"Pronk","given":"Melanie","roleDisplay":"VerfasserIn","display":"Pronk, Melanie","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ohletz, Jan","given":"Jan","family":"Ohletz"},{"family":"Könnecke","given":"Andreas","display":"Könnecke, Andreas","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Müller, Verena","roleDisplay":"VerfasserIn","role":"aut","family":"Müller","given":"Verena"},{"roleDisplay":"VerfasserIn","display":"Utikal, Jochen","role":"aut","family":"Utikal","given":"Jochen"},{"roleDisplay":"VerfasserIn","display":"Hillen, Uwe","role":"aut","family":"Hillen","given":"Uwe"},{"roleDisplay":"VerfasserIn","display":"Harth, Wolfgang","role":"aut","family":"Harth","given":"Wolfgang"},{"given":"Wiebke K.","family":"Peitsch","role":"aut","roleDisplay":"VerfasserIn","display":"Peitsch, Wiebke K."}],"title":[{"title_sort":"Patient preferences in adjuvant and palliative treatment of advanced melanoma","title":"Patient preferences in adjuvant and palliative treatment of advanced melanoma","subtitle":"a discrete choice experiment"}],"note":["Gesehen am 09.07.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1724133446","language":["eng"],"name":{"displayForm":["Juliane Weilandt, Katharina Diehl, Marthe-Lisa Schaarschmidt, Felix Kiecker, Bianca Sasama, Melanie Pronk, Jan Ohletz, Andreas Könnecke, Verena Müller, Jochen Utikal, Uwe Hillen, Wolfgang Harth and Wiebke K. Peitsch"]},"origin":[{"dateIssuedDisp":"14 February 2020","dateIssuedKey":"2020"}],"id":{"doi":["10.2340/00015555-3422"],"eki":["1724133446"]},"physDesc":[{"extent":"9 S."}],"relHost":[{"origin":[{"publisherPlace":"Uppsala ; Uppsala ; London [u.a.]","publisher":"Acta Dermato-Venereologica ; Medical Journals Sweden AB ; Taylor & Francis","dateIssuedDisp":"[1921?]-"}],"id":{"zdb":["1492617-9"],"eki":["302725431"],"issn":["1651-2057"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Acta dermato-venereologica","title":"Acta dermato-venereologica","subtitle":"a journal for clinical and experimental research in the field of dermatology and venereology"}],"pubHistory":["Volume 2, issue 2 (1921) [?]-"],"part":{"volume":"100","text":"100(2020,3) Artikel-Nummer adv00083, 9 Seiten","extent":"9","year":"2020","issue":"3"},"titleAlt":[{"title":"ActaDV"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Patient preferences in adjuvant and palliative treatment of advanced melanoma a discrete choice experimentActa dermato-venereologica","note":["Fortsetzung der Druck-Ausgabe","Volltext auch als Teil einer Datenbank verfügbar","Gesehen am 16.10.24"],"recId":"302725431","language":["eng"]}]} | ||
| SRT | |a WEILANDTJUPATIENTPRE1420 | ||