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Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis

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Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) have a similar clinical phenotype but represent distinct diseases, requiring different therapies. MicroRNAs (miRNAs) are short non-coding RNAs whose expression profiles can serve as diagnostic biomarkers and which may be invo...

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Bibliographic Details
Main Authors: Keller, Andreas (Author) , Haas, Jan (Author) , Jarius, Sven (Author) , Meder, Benjamin (Author)
Format: Article (Journal)
Language:English
Published: 31 October 2015
In: Journal of neuroinflammation
Year: 2015, Volume: 12, Issue: 1
ISSN:1742-2094
DOI:10.1186/s12974-015-0418-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12974-015-0418-1
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Author Notes:Andreas Keller, Petra Leidinger, Eckart Meese, Jan Haas, Christina Backes, Ludwig Rasche, Janina R. Behrens, Catherina Pfuhl, Katharina Wakonig, René M. Gieß, Sven Jarius, Benjamin Meder, Judith Bellmann-Strobl, Friedemann Paul, Florence C. Pache and Klemens Ruprecht
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Summary:Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) have a similar clinical phenotype but represent distinct diseases, requiring different therapies. MicroRNAs (miRNAs) are short non-coding RNAs whose expression profiles can serve as diagnostic biomarkers and which may be involved in the pathophysiology of neuroinflammatory diseases. Here, we analyzed miRNA profiles in serum and whole blood of patients with NMOSD and clinically isolated syndrome (CIS)/relapsing-remitting MS (RRMS) as well as healthy controls by next-generation sequencing (NGS).
Item Description:Gesehen am 17.07.2020
Physical Description:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-015-0418-1

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