Cover Image

A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis

Cell-cell communication is essential for multicellular development and, consequently, evolution has brought about an array of distinct mechanisms serving this purpose. Consistently, induction and maintenance of stem cell fate by noncell autonomous signals is a feature shared by many organisms and ma...

Full description

Saved in:
Bibliographic Details
Main Authors: Daum, Gabor (Author) , Medzihradszky, Anna (Author) , Suzaki, Takuya (Author) , Lohmann, Jan U. (Author)
Format: Article (Journal)
Language:English
Published: October 7, 2014
In: Proceedings of the National Academy of Sciences of the United States of America
Year: 2014, Volume: 111, Issue: 40, Pages: 14619-14624
ISSN:1091-6490
DOI:10.1073/pnas.1406446111
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.1406446111
Verlag, lizenzpflichtig, Volltext: https://www.pnas.org/content/111/40/14619
Get full text
Author Notes:Gabor Daum, Anna Medzihradszky, Takuya Suzaki, and Jan U. Lohmann

MARC

LEADER 00000caa a2200000 c 4500
001 1724646982
003 DE-627
005 20220818150301.0
007 cr uuu---uuuuu
008 200714s2014 xx |||||o 00| ||eng c
024 7 |a 10.1073/pnas.1406446111  |2 doi 
035 |a (DE-627)1724646982 
035 |a (DE-599)KXP1724646982 
035 |a (OCoLC)1341345133 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Daum, Gabor  |e VerfasserIn  |0 (DE-588)1071012010  |0 (DE-627)825507758  |0 (DE-576)432878521  |4 aut 
245 1 2 |a A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis  |c Gabor Daum, Anna Medzihradszky, Takuya Suzaki, and Jan U. Lohmann 
264 1 |c October 7, 2014 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 14.07.2020 
520 |a Cell-cell communication is essential for multicellular development and, consequently, evolution has brought about an array of distinct mechanisms serving this purpose. Consistently, induction and maintenance of stem cell fate by noncell autonomous signals is a feature shared by many organisms and may depend on secreted factors, direct cell-cell contact, matrix interactions, or a combination of these mechanisms. Although many basic cellular processes are well conserved between animals and plants, cell-to-cell signaling is one function where substantial diversity has arisen between the two kingdoms of life. One of the most striking differences is the presence of cytoplasmic bridges, called plasmodesmata, which facilitate the exchange of molecules between neighboring plant cells and provide a unique route for cell-cell communication in the plant lineage. Here, we provide evidence that the stem cell inducing transcription factor WUSCHEL (WUS), expressed in the niche, moves to the stem cells via plasmodesmata in a highly regulated fashion and that this movement is required for WUS function and, thus, stem cell activity in Arabidopsis thaliana. We show that cell context-independent mobility is encoded in the WUS protein sequence and mediated by multiple domains. Finally, we demonstrate that parts of the protein that restrict movement are required for WUS homodimerization, suggesting that formation of WUS dimers might contribute to the regulation of apical stem cell activity. 
650 4 |a cell-to-cell trafficking 
650 4 |a SAM 
650 4 |a shoot apical meristem 
650 4 |a transcription factor mobility 
700 1 |a Medzihradszky, Anna  |e VerfasserIn  |0 (DE-588)1071011901  |0 (DE-627)825507634  |0 (DE-576)432878513  |4 aut 
700 1 |a Suzaki, Takuya  |e VerfasserIn  |0 (DE-588)1131384881  |0 (DE-627)886046491  |0 (DE-576)488257751  |4 aut 
700 1 |a Lohmann, Jan U.  |d 1971-  |e VerfasserIn  |0 (DE-588)121572315  |0 (DE-627)70554642X  |0 (DE-576)292778627  |4 aut 
773 0 8 |i Enthalten in  |a National Academy of Sciences (Washington, DC)  |t Proceedings of the National Academy of Sciences of the United States of America  |d Washington, DC : National Acad. of Sciences, 1915  |g 111(2014), 40, Seite 14619-14624  |h Online-Ressource  |w (DE-627)254235379  |w (DE-600)1461794-8  |w (DE-576)073260509  |x 1091-6490  |7 nnas 
773 1 8 |g volume:111  |g year:2014  |g number:40  |g pages:14619-14624  |g extent:6  |a A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis 
856 4 0 |u https://doi.org/10.1073/pnas.1406446111  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.pnas.org/content/111/40/14619  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200714 
993 |a Article 
994 |a 2014 
998 |g 121572315  |a Lohmann, Jan U.  |m 121572315:Lohmann, Jan U.  |d 700000  |d 721000  |e 700000PL121572315  |e 721000PL121572315  |k 0/700000/  |k 1/700000/721000/  |p 4  |y j 
998 |g 1131384881  |a Suzaki, Takuya  |m 1131384881:Suzaki, Takuya  |p 3 
998 |g 1071011901  |a Medzihradszky, Anna  |m 1071011901:Medzihradszky, Anna  |d 700000  |d 721000  |e 700000PM1071011901  |e 721000PM1071011901  |k 0/700000/  |k 1/700000/721000/  |p 2 
998 |g 1071012010  |a Daum, Gabor  |m 1071012010:Daum, Gabor  |d 700000  |d 721000  |e 700000PD1071012010  |e 721000PD1071012010  |k 0/700000/  |k 1/700000/721000/  |p 1  |x j 
999 |a KXP-PPN1724646982  |e 3724180594 
BIB |a Y 
SER |a journal 
JSO |a {"title":[{"title_sort":"mechanistic framework for noncell autonomous stem cell induction in Arabidopsis","title":"A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis"}],"person":[{"given":"Gabor","family":"Daum","role":"aut","display":"Daum, Gabor","roleDisplay":"VerfasserIn"},{"given":"Anna","family":"Medzihradszky","role":"aut","roleDisplay":"VerfasserIn","display":"Medzihradszky, Anna"},{"given":"Takuya","family":"Suzaki","role":"aut","display":"Suzaki, Takuya","roleDisplay":"VerfasserIn"},{"family":"Lohmann","given":"Jan U.","roleDisplay":"VerfasserIn","display":"Lohmann, Jan U.","role":"aut"}],"recId":"1724646982","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 14.07.2020"],"id":{"doi":["10.1073/pnas.1406446111"],"eki":["1724646982"]},"origin":[{"dateIssuedDisp":"October 7, 2014","dateIssuedKey":"2014"}],"name":{"displayForm":["Gabor Daum, Anna Medzihradszky, Takuya Suzaki, and Jan U. Lohmann"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1461794-8"],"eki":["254235379"],"issn":["1091-6490"]},"origin":[{"dateIssuedDisp":"1915-","publisher":"National Acad. of Sciences","dateIssuedKey":"1915","publisherPlace":"Washington, DC"}],"recId":"254235379","corporate":[{"display":"National Academy of Sciences","roleDisplay":"VerfasserIn","role":"aut"}],"language":["eng"],"note":["Gesehen am 09.03.2022"],"disp":"National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America","type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"PNAS online"},{"title":"PNAS"}],"part":{"extent":"6","text":"111(2014), 40, Seite 14619-14624","volume":"111","pages":"14619-14624","issue":"40","year":"2014"},"pubHistory":["1.1915 -"],"title":[{"title_sort":"Proceedings of the National Academy of Sciences of the United States of America","title":"Proceedings of the National Academy of Sciences of the United States of America"}]}],"physDesc":[{"extent":"6 S."}]} 
SRT |a DAUMGABORMMECHANISTI7201 

Similar Items