Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer
Tumors are influenced by the mechanical properties of their microenvironment. Using patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver metastases than in primary colorectal tumors. Highly activated metastasis-associated fibroblasts increase tissue stiffnes...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 8, 2020
|
| In: |
Cancer cell
Year: 2020, Jahrgang: 37, Heft: 6, Pages: 800-817 |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2020.05.005 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: http://dx.doi.org/10.1016/j.ccell.2020.05.005
|
| Verfasserangaben: | Ying Shen, Xiaohong Wang, Junyan Lu, Martin Salfenmoser, Naita Maren Wirsik, Nikolai Schleussner, Andrea Imle, Aida Freire Valls, Praveen Radhakrishnan, Jie Liang, Guoliang Wang, Thomas Muley, Martin Schneider, Carmen Ruiz de Almodovar, Alba Diz-Muñoz, and Thomas Schmidt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1724725807 | ||
| 003 | DE-627 | ||
| 005 | 20230831150121.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200714s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ccell.2020.05.005 |2 doi | |
| 035 | |a (DE-627)1724725807 | ||
| 035 | |a (DE-599)KXP1724725807 | ||
| 035 | |a (OCoLC)1341345450 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Shen, Ying |d 1987- |e VerfasserIn |0 (DE-588)1144909899 |0 (DE-627)1005039518 |0 (DE-576)495511676 |4 aut | |
| 245 | 1 | 0 | |a Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer |c Ying Shen, Xiaohong Wang, Junyan Lu, Martin Salfenmoser, Naita Maren Wirsik, Nikolai Schleussner, Andrea Imle, Aida Freire Valls, Praveen Radhakrishnan, Jie Liang, Guoliang Wang, Thomas Muley, Martin Schneider, Carmen Ruiz de Almodovar, Alba Diz-Muñoz, and Thomas Schmidt |
| 264 | 1 | |c June 8, 2020 | |
| 300 | |a 18 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.07.2020 | ||
| 520 | |a Tumors are influenced by the mechanical properties of their microenvironment. Using patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver metastases than in primary colorectal tumors. Highly activated metastasis-associated fibroblasts increase tissue stiffness, which enhances angiogenesis and anti-angiogenic therapy resistance. Drugs targeting the renin-angiotensin system, normally prescribed to treat hypertension, inhibit fibroblast contraction and extracellular matrix deposition, thereby reducing liver metastases stiffening and increasing the anti-angiogenic effects of bevacizumab. Patients treated with bevacizumab showed prolonged survival when concomitantly treated with renin-angiotensin inhibitors, highlighting the importance of modulating the mechanical microenvironment for therapeutic regimens. | ||
| 650 | 4 | |a activation protein | |
| 650 | 4 | |a carcinoma-associated fibroblasts | |
| 650 | 4 | |a extracellular-matrix | |
| 650 | 4 | |a fibrotic focus | |
| 650 | 4 | |a focal adhesion maturation | |
| 650 | 4 | |a lysyl oxidase | |
| 650 | 4 | |a renin-angiotensin system | |
| 650 | 4 | |a stress | |
| 650 | 4 | |a tissue growth-factor | |
| 650 | 4 | |a tumor vasculature | |
| 700 | 1 | |a Wang, Xiaohong |e VerfasserIn |0 (DE-588)1144909244 |0 (DE-627)1005038678 |0 (DE-576)495511048 |4 aut | |
| 700 | 1 | |a Lu, Junyan |e VerfasserIn |0 (DE-588)124416478X |0 (DE-627)1775109585 |4 aut | |
| 700 | 1 | |a Salfenmoser, Martin |d 1992- |e VerfasserIn |0 (DE-588)1299868789 |0 (DE-627)1857263529 |4 aut | |
| 700 | 1 | |a Wirsik, Naita Maren |e VerfasserIn |0 (DE-588)1213759447 |0 (DE-627)1724667513 |4 aut | |
| 700 | 1 | |a Schleußner, Nikolai |e VerfasserIn |0 (DE-588)1209925583 |0 (DE-627)1697871747 |4 aut | |
| 700 | 1 | |a Imle, Andrea |e VerfasserIn |0 (DE-588)1081196815 |0 (DE-627)845673068 |0 (DE-576)454020066 |4 aut | |
| 700 | 1 | |a Freire Valls, Aida |e VerfasserIn |0 (DE-588)114490904X |0 (DE-627)1005038384 |0 (DE-576)495511102 |4 aut | |
| 700 | 1 | |a Radhakrishnan, Praveen |d 1985- |e VerfasserIn |0 (DE-588)1082783137 |0 (DE-627)84779220X |0 (DE-576)455565694 |4 aut | |
| 700 | 1 | |a Liang, Jie |e VerfasserIn |0 (DE-588)1172949972 |0 (DE-627)1042027579 |0 (DE-576)51491517X |4 aut | |
| 700 | 1 | |a Wang, Guoliang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Muley, Thomas |e VerfasserIn |0 (DE-588)1056885432 |0 (DE-627)794179169 |0 (DE-576)16759284X |4 aut | |
| 700 | 1 | |a Schneider, Martin |d 1976- |e VerfasserIn |0 (DE-588)12390384X |0 (DE-627)706468147 |0 (DE-576)42325037X |4 aut | |
| 700 | 1 | |a Ruiz de Almodóvar, Carmen |e VerfasserIn |0 (DE-588)1073942848 |0 (DE-627)830007776 |0 (DE-576)435417479 |4 aut | |
| 700 | 1 | |a Diz Muñoz, Alba |e VerfasserIn |0 (DE-588)1147157030 |0 (DE-627)1005992509 |0 (DE-576)350777152 |4 aut | |
| 700 | 1 | |a Schmidt, Thomas |d 1980- |e VerfasserIn |0 (DE-588)132383152 |0 (DE-627)521950023 |0 (DE-576)260799149 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer cell |d Cambridge, Mass. : Cell Press, 2002 |g 37(2020), 6, Seite 800-817 |h Online-Ressource |w (DE-627)343970082 |w (DE-600)2074034-7 |w (DE-576)097935972 |x 1878-3686 |7 nnas |a Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer |
| 773 | 1 | 8 | |g volume:37 |g year:2020 |g number:6 |g pages:800-817 |g extent:18 |a Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ccell.2020.05.005 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200714 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 132383152 |a Schmidt, Thomas |m 132383152:Schmidt, Thomas |d 910000 |d 910200 |d 50000 |e 910000PS132383152 |e 910200PS132383152 |e 50000PS132383152 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 16 |y j | ||
| 998 | |g 1073942848 |a Ruiz de Almodóvar, Carmen |m 1073942848:Ruiz de Almodóvar, Carmen |d 60000 |d 65000 |e 60000PR1073942848 |e 65000PR1073942848 |k 0/60000/ |k 1/60000/65000/ |p 14 | ||
| 998 | |g 12390384X |a Schneider, Martin |m 12390384X:Schneider, Martin |d 910000 |d 910200 |e 910000PS12390384X |e 910200PS12390384X |k 0/910000/ |k 1/910000/910200/ |p 13 | ||
| 998 | |g 1056885432 |a Muley, Thomas |m 1056885432:Muley, Thomas |d 910000 |d 950000 |d 950900 |e 910000PM1056885432 |e 950000PM1056885432 |e 950900PM1056885432 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 12 | ||
| 998 | |g 1172949972 |a Liang, Jie |m 1172949972:Liang, Jie |d 910000 |d 911600 |e 910000PL1172949972 |e 911600PL1172949972 |k 0/910000/ |k 1/910000/911600/ |p 10 | ||
| 998 | |g 1082783137 |a Radhakrishnan, Praveen |m 1082783137:Radhakrishnan, Praveen |p 9 | ||
| 998 | |g 114490904X |a Freire Valls, Aida |m 114490904X:Freire Valls, Aida |p 8 | ||
| 998 | |g 1081196815 |a Imle, Andrea |m 1081196815:Imle, Andrea |d 50000 |e 50000PI1081196815 |k 0/50000/ |p 7 | ||
| 998 | |g 1209925583 |a Schleußner, Nikolai |m 1209925583:Schleußner, Nikolai |d 910000 |d 910200 |e 910000PS1209925583 |e 910200PS1209925583 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 1213759447 |a Wirsik, Naita Maren |m 1213759447:Wirsik, Naita Maren |d 910000 |d 910200 |e 910000PW1213759447 |e 910200PW1213759447 |k 0/910000/ |k 1/910000/910200/ |p 5 | ||
| 998 | |g 1299868789 |a Salfenmoser, Martin |m 1299868789:Salfenmoser, Martin |d 50000 |e 50000PS1299868789 |k 0/50000/ |p 4 | ||
| 998 | |g 1144909244 |a Wang, Xiaohong |m 1144909244:Wang, Xiaohong |p 2 | ||
| 998 | |g 1144909899 |a Shen, Ying |m 1144909899:Shen, Ying |d 50000 |e 50000PS1144909899 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1724725807 |e 3724270119 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1724725807","note":["Gesehen am 14.07.2020"],"name":{"displayForm":["Ying Shen, Xiaohong Wang, Junyan Lu, Martin Salfenmoser, Naita Maren Wirsik, Nikolai Schleussner, Andrea Imle, Aida Freire Valls, Praveen Radhakrishnan, Jie Liang, Guoliang Wang, Thomas Muley, Martin Schneider, Carmen Ruiz de Almodovar, Alba Diz-Muñoz, and Thomas Schmidt"]},"relHost":[{"note":["Gesehen am 28.02.11"],"pubHistory":["1.2002 -"],"recId":"343970082","disp":"Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancerCancer cell","part":{"year":"2020","extent":"18","issue":"6","volume":"37","pages":"800-817","text":"37(2020), 6, Seite 800-817"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Cancer cell","title":"Cancer cell"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"eki":["343970082"],"issn":["1878-3686"],"zdb":["2074034-7"]},"language":["eng"],"origin":[{"publisherPlace":"Cambridge, Mass. ; New York, NY","dateIssuedDisp":"2002-","dateIssuedKey":"2002","publisher":"Cell Press ; Elsevier"}]}],"person":[{"role":"aut","given":"Ying","family":"Shen","display":"Shen, Ying"},{"family":"Wang","display":"Wang, Xiaohong","given":"Xiaohong","role":"aut"},{"role":"aut","given":"Junyan","family":"Lu","display":"Lu, Junyan"},{"family":"Salfenmoser","display":"Salfenmoser, Martin","given":"Martin","role":"aut"},{"given":"Naita Maren","display":"Wirsik, Naita Maren","family":"Wirsik","role":"aut"},{"role":"aut","display":"Schleußner, Nikolai","family":"Schleußner","given":"Nikolai"},{"role":"aut","display":"Imle, Andrea","family":"Imle","given":"Andrea"},{"family":"Freire Valls","display":"Freire Valls, Aida","given":"Aida","role":"aut"},{"role":"aut","given":"Praveen","display":"Radhakrishnan, Praveen","family":"Radhakrishnan"},{"given":"Jie","family":"Liang","display":"Liang, Jie","role":"aut"},{"role":"aut","family":"Wang","display":"Wang, Guoliang","given":"Guoliang"},{"role":"aut","family":"Muley","display":"Muley, Thomas","given":"Thomas"},{"role":"aut","family":"Schneider","display":"Schneider, Martin","given":"Martin"},{"family":"Ruiz de Almodóvar","display":"Ruiz de Almodóvar, Carmen","given":"Carmen","role":"aut"},{"role":"aut","display":"Diz Muñoz, Alba","family":"Diz Muñoz","given":"Alba"},{"display":"Schmidt, Thomas","family":"Schmidt","given":"Thomas","role":"aut"}],"physDesc":[{"extent":"18 S."}],"title":[{"title_sort":"Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer","title":"Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer"}],"id":{"eki":["1724725807"],"doi":["10.1016/j.ccell.2020.05.005"]},"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"June 8, 2020","dateIssuedKey":"2020"}]} | ||
| SRT | |a SHENYINGWAREDUCTIONO8202 | ||