Cover Image

Paracrine effects of mesenchymal stem cells induce senescence and differentiation of glioblastoma stem-like cells

Glioblastoma multiforme (GBM) displays high resistance to radiation and chemotherapy, due to the presence of a fraction of GBM stem-like cells (GSLCs), which are thus representing the target for GBM elimination. Since mesenchymal stem cells (MSCs) display high tumor tropism, we examined possible ant...

Full description

Saved in:
Bibliographic Details
Main Authors: Kološa, Katja (Author) , Motaln, Helena (Author) , Herold-Mende, Christel (Author) , Koršič, Marjan (Author) , Lah, Tamara T. (Author)
Format: Article (Journal)
Language:English
Published: March 24, 2015
In: Cell transplantation
Year: 2015, Volume: 24, Issue: 4, Pages: 631-644
ISSN:1555-3892
DOI:10.3727/096368915X687787
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3727/096368915X687787
Verlag, lizenzpflichtig, Volltext: https://journals.sagepub.com/doi/full/10.3727/096368915X687787
Get full text
Author Notes:Katja Kološa, Helena Motaln, Christel Herold-Mende, Marjan Koršič, and Tamara T. Lah
Description
Summary:Glioblastoma multiforme (GBM) displays high resistance to radiation and chemotherapy, due to the presence of a fraction of GBM stem-like cells (GSLCs), which are thus representing the target for GBM elimination. Since mesenchymal stem cells (MSCs) display high tumor tropism, we examined possible antitumor effects of the secreted factors from human MSCs on four GSLC lines (NCH421k, NCH644, NIB26, and NIB50).
Item Description:Gesehen am 15.07.2020
Physical Description:Online Resource
ISSN:1555-3892
DOI:10.3727/096368915X687787

Similar Items