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Paracrine effects of mesenchymal stem cells induce senescence and differentiation of glioblastoma stem-like cells

Glioblastoma multiforme (GBM) displays high resistance to radiation and chemotherapy, due to the presence of a fraction of GBM stem-like cells (GSLCs), which are thus representing the target for GBM elimination. Since mesenchymal stem cells (MSCs) display high tumor tropism, we examined possible ant...

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Hauptverfasser: Kološa, Katja (VerfasserIn) , Motaln, Helena (VerfasserIn) , Herold-Mende, Christel (VerfasserIn) , Koršič, Marjan (VerfasserIn) , Lah, Tamara T. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: March 24, 2015
In: Cell transplantation
Year: 2015, Jahrgang: 24, Heft: 4, Pages: 631-644
ISSN:1555-3892
DOI:10.3727/096368915X687787
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3727/096368915X687787
Verlag, lizenzpflichtig, Volltext: https://journals.sagepub.com/doi/full/10.3727/096368915X687787
Volltext
Verfasserangaben:Katja Kološa, Helena Motaln, Christel Herold-Mende, Marjan Koršič, and Tamara T. Lah
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Zusammenfassung:Glioblastoma multiforme (GBM) displays high resistance to radiation and chemotherapy, due to the presence of a fraction of GBM stem-like cells (GSLCs), which are thus representing the target for GBM elimination. Since mesenchymal stem cells (MSCs) display high tumor tropism, we examined possible antitumor effects of the secreted factors from human MSCs on four GSLC lines (NCH421k, NCH644, NIB26, and NIB50).
Beschreibung:Gesehen am 15.07.2020
Beschreibung:Online Resource
ISSN:1555-3892
DOI:10.3727/096368915X687787

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