Drug target identification using a trypanosome overexpression library
Elucidation of molecular targets is very important for lead optimization during the drug development process. We describe a direct method to find targets of antitrypanosomal compounds against Trypanosoma brucei using a trypanosome overexpression library. As proof of concept, we treated the library w...
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| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 July 2014
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| In: |
Antimicrobial agents and chemotherapy
Year: 2014, Volume: 58, Issue: 10, Pages: 6260-6264 |
| ISSN: | 1098-6596 |
| DOI: | 10.1128/AAC.03338-14 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/AAC.03338-14 Verlag, lizenzpflichtig, Volltext: https://aac.asm.org/content/58/10/6260 
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| Author Notes: | Daniela Begolo, Esteban Erben, Christine Clayton |
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| 520 | |a Elucidation of molecular targets is very important for lead optimization during the drug development process. We describe a direct method to find targets of antitrypanosomal compounds against Trypanosoma brucei using a trypanosome overexpression library. As proof of concept, we treated the library with difluoromethylornithine and DDD85646 and identified their respective targets, ornithine decarboxylase and N-myristoyltransferase. The overexpression library could be a useful tool to study the modes of action of novel antitrypanosomal drug candidates. | ||
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