β-catenin-independent roles of Wnt/LRP6 signaling
Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 August 2016
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| In: |
Trends in cell biology
Year: 2016, Jahrgang: 26, Heft: 12, Pages: 956-967 |
| ISSN: | 1879-3088 |
| DOI: | 10.1016/j.tcb.2016.07.009 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tcb.2016.07.009 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0962892416301027 
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| Verfasserangaben: | Sergio P. Acebron and Christof Niehrs |
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| 520 | |a Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology. | ||
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