Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission
Herein we aimed to understand how nanoscale clustering of RGD ligands alters the mechano-regulation of their integrin receptors. We combined molecular tension fluorescence microscopy with block copolymer micelle nanolithography to fabricate substrates with arrays of precisely spaced probes that can...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 19, 2014
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| In: |
Nano letters
Year: 2014, Jahrgang: 14, Heft: 10, Pages: 5539-5546 |
| ISSN: | 1530-6992 |
| DOI: | 10.1021/nl501912g |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl501912g
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| Verfasserangaben: | Yang Liu, Rebecca Medda, Zheng Liu, Kornelia Galior, Kevin Yehl, Joachim P. Spatz, Elisabetta Ada Cavalcanti-Adam, and Khalid Salaita |
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| 520 | |a Herein we aimed to understand how nanoscale clustering of RGD ligands alters the mechano-regulation of their integrin receptors. We combined molecular tension fluorescence microscopy with block copolymer micelle nanolithography to fabricate substrates with arrays of precisely spaced probes that can generate a 10-fold fluorescence response to pN-forces. We found that the mechanism of sensing ligand spacing is force-mediated. This strategy is broadly applicable to investigating receptor clustering and its role in mechanotransduction pathways. | ||
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