Buchumschlag

The sweet quartet: binding of fucose to the norovirus capsid

Human noroviruses bind histo-blood group antigens (HBGAs) and this interaction is thought to be important for an infection. We identified two additional fucose-binding pockets (termed fucose-3/4 sites) on a genogroup II human (GII.10) norovirus-protruding (P) dimer using X-ray crystallography. Fucos...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Koromyslova, Anna D. (VerfasserIn) , Leuthold, Mila (VerfasserIn) , Bowler, Matthew W. (VerfasserIn) , Hansman, Grant S. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 May 2015
In: Virology
Year: 2015, Jahrgang: 483, Pages: 203-208
ISSN:1096-0341
DOI:10.1016/j.virol.2015.04.006
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.virol.2015.04.006
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0042682215002032
Volltext
Verfasserangaben:Anna D. Koromyslova, Mila M. Leuthold, Matthew W. Bowler, Grant S. Hansman

MARC

LEADER 00000caa a2200000 c 4500
001 1725264080
003 DE-627
005 20230426183710.0
007 cr uuu---uuuuu
008 200722s2015 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.virol.2015.04.006  |2 doi 
035 |a (DE-627)1725264080 
035 |a (DE-599)KXP1725264080 
035 |a (OCoLC)1341347454 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Koromyslova, Anna D.  |e VerfasserIn  |0 (DE-588)113528248X  |0 (DE-627)890241414  |0 (DE-576)489738842  |4 aut 
245 1 4 |a The sweet quartet  |b binding of fucose to the norovirus capsid  |c Anna D. Koromyslova, Mila M. Leuthold, Matthew W. Bowler, Grant S. Hansman 
264 1 |c 15 May 2015 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 22.07.2020 
520 |a Human noroviruses bind histo-blood group antigens (HBGAs) and this interaction is thought to be important for an infection. We identified two additional fucose-binding pockets (termed fucose-3/4 sites) on a genogroup II human (GII.10) norovirus-protruding (P) dimer using X-ray crystallography. Fucose-3/4 sites were located between two previously determined HBGA binding pockets (termed fucose-1/2 sites). We found that four fucose molecules were capable of binding altogether at fucose-1/2/3/4 sites on the P dimer, though the fucose molecules bound in a dose-dependent and step-wise manner. We also showed that HBGA B-trisaccharide molecules bound in a similar way at the fucose-1/2 sites. Interestingly, we discovered that the monomers of the P dimer were asymmetrical in an unliganded state and when a single B-trisaccharide molecule bound, but were symmetrical when two B-trisaccharide molecules bound. We postulate that the symmetrical dimers might favor HBGA binding interactions at fucose-1/2 sites. 
650 4 |a Capsid 
650 4 |a Fucose 
650 4 |a Histo-blood group antigens (HBGAs) 
650 4 |a Norovirus 
700 1 |a Leuthold, Mila  |e VerfasserIn  |0 (DE-588)1113305134  |0 (DE-627)867172029  |0 (DE-576)476948304  |4 aut 
700 1 |a Bowler, Matthew W.  |e VerfasserIn  |4 aut 
700 1 |a Hansman, Grant S.  |e VerfasserIn  |0 (DE-588)105917703X  |0 (DE-627)798127287  |0 (DE-576)325655553  |4 aut 
773 0 8 |i Enthalten in  |t Virology  |d San Diego, Calif. [u.a.] : Elsevier, 1955  |g 483(2015), Seite 203-208  |h Online-Ressource  |w (DE-627)268130248  |w (DE-600)1471925-3  |w (DE-576)104194081  |x 1096-0341  |7 nnas  |a The sweet quartet binding of fucose to the norovirus capsid 
773 1 8 |g volume:483  |g year:2015  |g pages:203-208  |g extent:6  |a The sweet quartet binding of fucose to the norovirus capsid 
856 4 0 |u https://doi.org/10.1016/j.virol.2015.04.006  |x Resolving-System  |x Verlag  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0042682215002032  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200722 
993 |a Article 
994 |a 2020 
998 |g 105917703X  |a Hansman, Grant S.  |m 105917703X:Hansman, Grant S.  |p 4  |y j 
998 |g 1113305134  |a Leuthold, Mila  |m 1113305134:Leuthold, Mila  |d 140000  |e 140000PL1113305134  |k 0/140000/  |p 2 
999 |a KXP-PPN1725264080  |e 3727874015 
BIB |a Y 
SER |a journal 
JSO |a {"title":[{"title_sort":"sweet quartet","subtitle":"binding of fucose to the norovirus capsid","title":"The sweet quartet"}],"person":[{"given":"Anna D.","family":"Koromyslova","role":"aut","display":"Koromyslova, Anna D.","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Leuthold, Mila","role":"aut","family":"Leuthold","given":"Mila"},{"roleDisplay":"VerfasserIn","display":"Bowler, Matthew W.","role":"aut","family":"Bowler","given":"Matthew W."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Hansman, Grant S.","given":"Grant S.","family":"Hansman"}],"recId":"1725264080","language":["eng"],"note":["Gesehen am 22.07.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1016/j.virol.2015.04.006"],"eki":["1725264080"]},"origin":[{"dateIssuedDisp":"15 May 2015","dateIssuedKey":"2015"}],"name":{"displayForm":["Anna D. Koromyslova, Mila M. Leuthold, Matthew W. Bowler, Grant S. Hansman"]},"relHost":[{"id":{"issn":["1096-0341"],"zdb":["1471925-3"],"eki":["268130248"]},"origin":[{"publisherPlace":"San Diego, Calif. [u.a.] ; Orlando, Fla.","dateIssuedKey":"1955","publisher":"Elsevier ; Academic Press","dateIssuedDisp":"1955-"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Virology","title":"Virology"}],"language":["eng"],"recId":"268130248","disp":"The sweet quartet binding of fucose to the norovirus capsidVirology","note":["Gesehen am 12.08.20"],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"pages":"203-208","year":"2015","extent":"6","volume":"483","text":"483(2015), Seite 203-208"},"pubHistory":["1.1955 -"]}],"physDesc":[{"extent":"6 S."}]} 
SRT |a KOROMYSLOVSWEETQUART1520 

Ähnliche Einträge