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Opening a niche for therapy: local lymphodepletion helps the immune system to fight melanoma

In this issue, Fujiwara et al. report that local ablation of CD4+ T cells in a murine B16 melanoma model, together with concomitant activation of the immune system by OX40L, leads to complete rejection of the melanomas. Rejection was driven mainly by CD8+ T cells, which infiltrated the melanomas and...

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Bibliographic Details
Main Authors: Mahnke, Karsten (Author) , Skorokhod, Alexander (Author) , Grabbe, Stefan (Author) , Enk, Alexander (Author)
Format: Article (Journal)
Language:English
Published: 2014
In: The journal of investigative dermatology
Year: 2014, Volume: 134, Issue: 7, Pages: 1794-1796
ISSN:1523-1747
DOI:10.1038/jid.2014.100
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/jid.2014.100
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0022202X15369050
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Author Notes:Karsten Mahnke, Alexander Skorokhod, Stefan Grabbe and Alexander H. Enk

MARC

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