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Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

Inserted (I) domains function as ligand-binding domains in adhesins that support cell adhesion and migration in many eukaryotic phyla. These adhesins include integrin αβ heterodimers in metazoans and single subunit transmembrane proteins in apicomplexans such as TRAP in Plasmodium and MIC2 in Toxopl...

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Hauptverfasser: Klug, Dennis (VerfasserIn) , Göllner, Sarah (VerfasserIn) , Kehrer, Jessica (VerfasserIn) , Sattler, Julia M. (VerfasserIn) , Strauss, Léanne (VerfasserIn) , Singer, Mirko (VerfasserIn) , Lu, Chafen (VerfasserIn) , Springer, Timothy A (VerfasserIn) , Frischknecht, Friedrich (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 July 2020
In: eLife
Year: 2020, Jahrgang: 9
ISSN:2050-084X
DOI:10.7554/eLife.57572
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.57572
Verlag, lizenzpflichtig, Volltext: https://elifesciences.org/articles/57572
Volltext
Verfasserangaben:Dennis Klug, Sarah Goellner, Jessica Kehrer, Julia Sattler, Léanne Strauss, Mirko Singer, Chafen Lu, Timothy A Springer, Friedrich Frischknecht
Beschreibung
Zusammenfassung:Inserted (I) domains function as ligand-binding domains in adhesins that support cell adhesion and migration in many eukaryotic phyla. These adhesins include integrin αβ heterodimers in metazoans and single subunit transmembrane proteins in apicomplexans such as TRAP in Plasmodium and MIC2 in Toxoplasma. Here we show that the I domain of TRAP is essential for sporozoite gliding motility, mosquito salivary gland invasion and mouse infection.
Beschreibung:Gesehen am 24.07.2020
Beschreibung:Online Resource
ISSN:2050-084X
DOI:10.7554/eLife.57572

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