An efficient tandem approach for the synthesis of functionalized 2-pyridone-3-carboxylic acids using three-component reaction in aqueous media
Novel analogs of 2-pyridone-3-carboxylic acids 4a-l have been prepared by the three-component reaction of 3-formyl chromone, Meldrum’s acid, and primary amines in the presence of a catalytic amount of diammonium hydrogen phosphate in water. Good-to-high yields, easy work-up, and an environmentally f...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
04 May 2014
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| In: |
Molecular diversity
Year: 2014, Jahrgang: 18, Heft: 3, Pages: 535-543 |
| ISSN: | 1573-501X |
| DOI: | 10.1007/s11030-014-9522-x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11030-014-9522-x
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| Verfasserangaben: | Saber Mehrparvar, Saeed Balalaie, Mahnaz Rabbanizadeh, Elmira Ghabraie, Frank Rominger |
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| 520 | |a Novel analogs of 2-pyridone-3-carboxylic acids 4a-l have been prepared by the three-component reaction of 3-formyl chromone, Meldrum’s acid, and primary amines in the presence of a catalytic amount of diammonium hydrogen phosphate in water. Good-to-high yields, easy work-up, and an environmentally friendly profile are the advantages of this method for the synthesis of 2-pyridone-3-carboxylic acid derivatives. | ||
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