Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement
Positioning the nucleus is critical for many cellular processes including cell division, migration and differentiation. The linker of nucleoskeleton and cytoskeleton (LINC) complex spans the inner and outer nuclear membranes and has emerged as a major factor in connecting the nucleus to the cytoskel...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 Jul 2015
|
| In: |
Cell cycle
Year: 2015, Volume: 14, Issue: 14, Pages: 2200-2205 |
| ISSN: | 1551-4005 |
| DOI: | 10.1080/15384101.2015.1053665 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/15384101.2015.1053665
|
| Author Notes: | Susumu Antoku, Ruijun Zhu, Stefan Kutscheidt, Oliver T. Fackler, and Gregg G. Gundersen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1725562235 | ||
| 003 | DE-627 | ||
| 005 | 20230426183812.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200727s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/15384101.2015.1053665 |2 doi | |
| 035 | |a (DE-627)1725562235 | ||
| 035 | |a (DE-599)KXP1725562235 | ||
| 035 | |a (OCoLC)1341347866 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Antoku, Susumu |e VerfasserIn |0 (DE-588)1214597084 |0 (DE-627)1725562200 |4 aut | |
| 245 | 1 | 0 | |a Reinforcing the LINC complex connection to actin filaments |b the role of FHOD1 in TAN line formation and nuclear movement |c Susumu Antoku, Ruijun Zhu, Stefan Kutscheidt, Oliver T. Fackler, and Gregg G. Gundersen |
| 264 | 1 | |c 01 Jul 2015 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.07.2020 | ||
| 520 | |a Positioning the nucleus is critical for many cellular processes including cell division, migration and differentiation. The linker of nucleoskeleton and cytoskeleton (LINC) complex spans the inner and outer nuclear membranes and has emerged as a major factor in connecting the nucleus to the cytoskeleton for movement and positioning. Recently, we discovered that the diaphanous formin family member FHOD1 interacts with the LINC complex component nesprin-2 giant (nesprin-2G) and that this interaction plays essential roles in the formation of transmembrane actin-dependent nuclear (TAN) lines and nuclear movement during cell polarization in fibroblasts. We found that FHOD1 strengthens the connection between nesprin-2G and rearward moving dorsal actin cables by providing a second site of interaction between nesprin-2G and the actin cable. These results indicate that the LINC complex connection to the actin cytoskeleton can be enhanced by cytoplasmic factors and suggest a new model for TAN line formation. We discuss how the nesprin-2G-FHOD1 interaction may be regulated and its possible functional significance for development and disease. | ||
| 650 | 4 | |a actin filaments | |
| 650 | 4 | |a Emery-Dreifuss muscular dystrophy | |
| 650 | 4 | |a FHOD1 | |
| 650 | 4 | |a formin | |
| 650 | 4 | |a LINC Complex | |
| 650 | 4 | |a nesprin | |
| 650 | 4 | |a nuclear movement | |
| 650 | 4 | |a TAN lines | |
| 700 | 1 | |a Zhu, Ruijun |e VerfasserIn |0 (DE-588)1159931283 |0 (DE-627)1023012391 |0 (DE-576)505398494 |4 aut | |
| 700 | 1 | |a Kutscheidt, Stefan |d 1979- |e VerfasserIn |0 (DE-588)1054560269 |0 (DE-627)791604241 |0 (DE-576)41032003X |4 aut | |
| 700 | 1 | |a Fackler, Oliver Till |e VerfasserIn |0 (DE-588)1026682444 |0 (DE-627)727057391 |0 (DE-576)178094501 |4 aut | |
| 700 | 1 | |a Gundersen, Gregg G. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell cycle |d Abingdon : Taylor & Francis Group, 2002 |g 14(2015), 14, Seite 2200-2205 |h Online-Ressource |w (DE-627)36373368X |w (DE-600)2102687-7 |w (DE-576)261570536 |x 1551-4005 |7 nnas |a Reinforcing the LINC complex connection to actin filaments the role of FHOD1 in TAN line formation and nuclear movement |
| 773 | 1 | 8 | |g volume:14 |g year:2015 |g number:14 |g pages:2200-2205 |g extent:6 |a Reinforcing the LINC complex connection to actin filaments the role of FHOD1 in TAN line formation and nuclear movement |
| 856 | 4 | 0 | |u https://doi.org/10.1080/15384101.2015.1053665 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200727 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1026682444 |a Fackler, Oliver Till |m 1026682444:Fackler, Oliver Till |d 910000 |d 911700 |e 910000PF1026682444 |e 911700PF1026682444 |k 0/910000/ |k 1/910000/911700/ |p 4 | ||
| 998 | |g 1054560269 |a Kutscheidt, Stefan |m 1054560269:Kutscheidt, Stefan |d 910000 |d 911700 |e 910000PK1054560269 |e 911700PK1054560269 |k 0/910000/ |k 1/910000/911700/ |p 3 | ||
| 999 | |a KXP-PPN1725562235 |e 372941397X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"note":["Gesehen am 27.07.2020"],"person":[{"family":"Antoku","role":"aut","display":"Antoku, Susumu","given":"Susumu"},{"display":"Zhu, Ruijun","role":"aut","family":"Zhu","given":"Ruijun"},{"given":"Stefan","display":"Kutscheidt, Stefan","role":"aut","family":"Kutscheidt"},{"family":"Fackler","role":"aut","display":"Fackler, Oliver Till","given":"Oliver Till"},{"role":"aut","family":"Gundersen","display":"Gundersen, Gregg G.","given":"Gregg G."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1725562235"],"doi":["10.1080/15384101.2015.1053665"]},"recId":"1725562235","origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"01 Jul 2015"}],"name":{"displayForm":["Susumu Antoku, Ruijun Zhu, Stefan Kutscheidt, Oliver T. Fackler, and Gregg G. Gundersen"]},"relHost":[{"disp":"Reinforcing the LINC complex connection to actin filaments the role of FHOD1 in TAN line formation and nuclear movementCell cycle","origin":[{"dateIssuedDisp":"2002-","publisherPlace":"Abingdon ; Georgetown, Tex","dateIssuedKey":"2002","publisher":"Taylor & Francis Group ; Landes Bioscience"}],"recId":"36373368X","id":{"eki":["36373368X"],"zdb":["2102687-7"],"issn":["1551-4005"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.2002 -"],"note":["Gesehen am 23.05.25"],"language":["eng"],"part":{"volume":"14","text":"14(2015), 14, Seite 2200-2205","issue":"14","pages":"2200-2205","year":"2015","extent":"6"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Cell cycle","title_sort":"Cell cycle"}]}],"title":[{"title":"Reinforcing the LINC complex connection to actin filaments","subtitle":"the role of FHOD1 in TAN line formation and nuclear movement","title_sort":"Reinforcing the LINC complex connection to actin filaments"}],"physDesc":[{"extent":"6 S."}]} | ||
| SRT | |a ANTOKUSUSUREINFORCIN0120 | ||