Cell culture models for hepatitis E virus
Despite a growing awareness, hepatitis E virus (HEV) remains understudied and investigations have been historically hampered by the absence of efficient cell culture systems. As a result, the pathogenesis of HEV infection and basic steps of the HEV life cycle are poorly understood. Major efforts hav...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 July 2019
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| In: |
Viruses
Year: 2020, Jahrgang: 11, Heft: 7 |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v11070608 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/v11070608 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1999-4915/11/7/608 
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| Verfasserangaben: | Rebecca Menhua Fu, Charlotte Caroline Decker and Viet Loan Dao Thi |
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| 520 | |a Despite a growing awareness, hepatitis E virus (HEV) remains understudied and investigations have been historically hampered by the absence of efficient cell culture systems. As a result, the pathogenesis of HEV infection and basic steps of the HEV life cycle are poorly understood. Major efforts have recently been made through the development of HEV infectious clones and cellular systems that significantly advanced HEV research. Here, we summarize these systems, discussing their advantages and disadvantages for HEV studies. We further capitalize on the need for HEV-permissive polarized cell models to better recapitulate the entire HEV life cycle and transmission. | ||
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