Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system
The improvement of treatment strategies in cardiovascular medicine is an ongoing process that requires constant optimization. The ability of a therapeutic intervention to prevent cardiovascular pathology largely depends on its capacity to suppress the underlying mechanisms. Attenuation or reversal o...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 March 2016
|
| In: |
Clinical science
Year: 2016, Jahrgang: 130, Heft: 9, Pages: 643-650 |
| ISSN: | 1470-8736 |
| DOI: | 10.1042/CS20150533 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1042/CS20150533 Verlag, lizenzpflichtig, Volltext: /clinsci/article/130/9/643/71520/Therapeutic-targeting-of-two-pore-domain-potassium 
|
| Verfasserangaben: | Felix Wiedmann, Constanze Schmidt, Patrick Lugenbiel, Ingo Staudacher, Ann-Kathrin Rahm, Claudia Seyler, Patrick A. Schweizer, Hugo A. Katus and Dierk Thomas |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1725674882 | ||
| 003 | DE-627 | ||
| 005 | 20230426183831.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200728s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1042/CS20150533 |2 doi | |
| 035 | |a (DE-627)1725674882 | ||
| 035 | |a (DE-599)KXP1725674882 | ||
| 035 | |a (OCoLC)1341348623 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wiedmann, Felix Tobias |d 1987- |e VerfasserIn |0 (DE-588)1055852441 |0 (DE-627)792733479 |0 (DE-576)411904159 |4 aut | |
| 245 | 1 | 0 | |a Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system |c Felix Wiedmann, Constanze Schmidt, Patrick Lugenbiel, Ingo Staudacher, Ann-Kathrin Rahm, Claudia Seyler, Patrick A. Schweizer, Hugo A. Katus and Dierk Thomas |
| 246 | 3 | 3 | |a Therapeutic targeting of two-pore-domain potassium (K 2P) channels in the cardiovascular system |
| 264 | 1 | |c 18 March 2016 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel ist der Ausdruck "2P" tiefgestellt | ||
| 500 | |a Gesehen am 28.07.2020 | ||
| 520 | |a The improvement of treatment strategies in cardiovascular medicine is an ongoing process that requires constant optimization. The ability of a therapeutic intervention to prevent cardiovascular pathology largely depends on its capacity to suppress the underlying mechanisms. Attenuation or reversal of disease-specific pathways has emerged as a promising paradigm, providing a mechanistic rationale for patient-tailored therapy. Two-pore-domain K+ (K2P) channels conduct outward K+ currents that stabilize the resting membrane potential and facilitate action potential repolarization. K2P expression in the cardiovascular system and polymodal K2P current regulation suggest functional significance and potential therapeutic roles of the channels. Recent work has focused primarily on K2P1.1 [tandem of pore domains in a weak inwardly rectifying K+ channel (TWIK)-1], K2P2.1 [TWIK-related K+ channel (TREK)-1], and K2P3.1 [TWIK-related acid-sensitive K+ channel (TASK)-1] channels and their role in heart and vessels. K2P currents have been implicated in atrial and ventricular arrhythmogenesis and in setting the vascular tone. Furthermore, the association of genetic alterations in K2P3.1 channels with atrial fibrillation, cardiac conduction disorders and pulmonary arterial hypertension demonstrates the relevance of the channels in cardiovascular disease. The function, regulation and clinical significance of cardiovascular K2P channels are summarized in the present review, and therapeutic options are emphasized. | ||
| 700 | 1 | |a Schmidt, Constanze |e VerfasserIn |0 (DE-588)1055852174 |0 (DE-627)792733142 |0 (DE-576)411903721 |4 aut | |
| 700 | 1 | |a Lugenbiel, Patrick |d 1982- |e VerfasserIn |0 (DE-588)137855710 |0 (DE-627)696120062 |0 (DE-576)305349414 |4 aut | |
| 700 | 1 | |a Staudacher, Ingo |d 1983- |e VerfasserIn |0 (DE-588)1034185543 |0 (DE-627)74489686X |0 (DE-576)381801527 |4 aut | |
| 700 | 1 | |a Rahm, Ann-Kathrin |d 1988- |e VerfasserIn |0 (DE-588)1054163049 |0 (DE-627)791115690 |0 (DE-576)410045217 |4 aut | |
| 700 | 1 | |a Seyler, Claudia |d 1976- |e VerfasserIn |0 (DE-588)13306476X |0 (DE-627)533316871 |0 (DE-576)299599523 |4 aut | |
| 700 | 1 | |a Schweizer, Patrick Alexander |d 1976- |e VerfasserIn |0 (DE-588)129886254 |0 (DE-627)48277987X |0 (DE-576)297887130 |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Thomas, Dierk |d 1974- |e VerfasserIn |0 (DE-588)123896258 |0 (DE-627)706465601 |0 (DE-576)29393164X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical science |d London : Portland, 1970 |g 130(2016), 9, Seite 643-650 |h Online-Ressource |w (DE-627)301116199 |w (DE-600)1484392-4 |w (DE-576)306828685 |x 1470-8736 |7 nnas |a Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system |
| 773 | 1 | 8 | |g volume:130 |g year:2016 |g number:9 |g pages:643-650 |g extent:8 |a Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system |
| 856 | 4 | 0 | |u https://doi.org/10.1042/CS20150533 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u /clinsci/article/130/9/643/71520/Therapeutic-targeting-of-two-pore-domain-potassium |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200728 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 123896258 |a Thomas, Dierk |m 123896258:Thomas, Dierk |d 910000 |d 910100 |e 910000PT123896258 |e 910100PT123896258 |k 0/910000/ |k 1/910000/910100/ |p 9 |y j | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |e 910000PK108916618 |e 910100PK108916618 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 129886254 |a Schweizer, Patrick Alexander |m 129886254:Schweizer, Patrick Alexander |d 910000 |d 910100 |e 910000PS129886254 |e 910100PS129886254 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 13306476X |a Seyler, Claudia |m 13306476X:Seyler, Claudia |d 910000 |d 910100 |e 910000PS13306476X |e 910100PS13306476X |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1054163049 |a Rahm, Ann-Kathrin |m 1054163049:Rahm, Ann-Kathrin |d 910000 |d 910100 |e 910000PR1054163049 |e 910100PR1054163049 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1034185543 |a Staudacher, Ingo |m 1034185543:Staudacher, Ingo |d 910000 |d 910100 |e 910000PS1034185543 |e 910100PS1034185543 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 137855710 |a Lugenbiel, Patrick |m 137855710:Lugenbiel, Patrick |d 910000 |d 910100 |e 910000PL137855710 |e 910100PL137855710 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1055852174 |a Schmidt, Constanze |m 1055852174:Schmidt, Constanze |d 910000 |d 910100 |e 910000PS1055852174 |e 910100PS1055852174 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1055852441 |a Wiedmann, Felix Tobias |m 1055852441:Wiedmann, Felix Tobias |d 910000 |d 910100 |e 910000PW1055852441 |e 910100PW1055852441 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1725674882 |e 3730956043 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1042/CS20150533"],"eki":["1725674882"]},"person":[{"display":"Wiedmann, Felix Tobias","roleDisplay":"VerfasserIn","role":"aut","family":"Wiedmann","given":"Felix Tobias"},{"display":"Schmidt, Constanze","given":"Constanze","family":"Schmidt","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Patrick","family":"Lugenbiel","display":"Lugenbiel, Patrick"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Staudacher","given":"Ingo","display":"Staudacher, Ingo"},{"display":"Rahm, Ann-Kathrin","family":"Rahm","given":"Ann-Kathrin","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Seyler, Claudia","role":"aut","roleDisplay":"VerfasserIn","given":"Claudia","family":"Seyler"},{"display":"Schweizer, Patrick Alexander","given":"Patrick Alexander","family":"Schweizer","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Hugo","family":"Katus","role":"aut","roleDisplay":"VerfasserIn","display":"Katus, Hugo"},{"given":"Dierk","family":"Thomas","role":"aut","roleDisplay":"VerfasserIn","display":"Thomas, Dierk"}],"relHost":[{"pubHistory":["Nachgewiesen 38.1970 -"],"title":[{"title_sort":"Clinical science","title":"Clinical science","subtitle":"online ; an international journal of clinical & molecular investigation"}],"titleAlt":[{"title":"Clinical science online"},{"title":"Clinical science and molecular medicine"}],"language":["eng"],"recId":"301116199","note":["Gesehen am 14.04.2025","Fortsetzung der Druck-Ausgabe"],"origin":[{"dateIssuedDisp":"1970-","dateIssuedKey":"1970","publisher":"Portland","publisherPlace":"London"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"part":{"year":"2016","volume":"130","text":"130(2016), 9, Seite 643-650","issue":"9","extent":"8","pages":"643-650"},"disp":"Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular systemClinical science","name":{"displayForm":["Medical Research Society ; Biochemical Society"]},"id":{"eki":["301116199"],"zdb":["1484392-4"],"issn":["1470-8736"]}}],"physDesc":[{"extent":"8 S."}],"name":{"displayForm":["Felix Wiedmann, Constanze Schmidt, Patrick Lugenbiel, Ingo Staudacher, Ann-Kathrin Rahm, Claudia Seyler, Patrick A. Schweizer, Hugo A. Katus and Dierk Thomas"]},"language":["eng"],"recId":"1725674882","titleAlt":[{"title":"Therapeutic targeting of two-pore-domain potassium (K 2P) channels in the cardiovascular system"}],"title":[{"title":"Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system","title_sort":"Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system"}],"note":["Im Titel ist der Ausdruck \"2P\" tiefgestellt","Gesehen am 28.07.2020"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"18 March 2016","dateIssuedKey":"2016"}]} | ||
| SRT | |a WIEDMANNFETHERAPEUTI1820 | ||