Pretreatment d -2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia
Mutations in isocitrate dehydrogenases (IDHs) 1 and 2 frequently occur in acute myeloid leukemia (AML) and result in the production of the oncometabolite d-2-hydroxyglutarate (D2HG). D2HG has been shown to promote leukemogenesis even in the absence of mutated IDH, but the prognostic significance of...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2016
|
| In: |
Leukemia
Year: 2015, Jahrgang: 30, Heft: 4, Pages: 782-788 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/leu.2015.317 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/leu.2015.317 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/leu2015317 
|
| Verfasserangaben: | J. Balss, C. Thiede, T. Bochtler, J.G. Okun, M. Saadati, A. Benner, S. Pusch, G. Ehninger, M. Schaich, A.D. Ho, A. von Deimling, A. Krämer and C E. Heilig |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1725851164 | ||
| 003 | DE-627 | ||
| 005 | 20220818163347.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200729r20162015xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/leu.2015.317 |2 doi | |
| 035 | |a (DE-627)1725851164 | ||
| 035 | |a (DE-599)KXP1725851164 | ||
| 035 | |a (OCoLC)1341348846 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Balß, Jörg |d 1976- |e VerfasserIn |0 (DE-588)133843173 |0 (DE-627)557777216 |0 (DE-576)30014296X |4 aut | |
| 245 | 1 | 0 | |a Pretreatment d -2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia |c J. Balss, C. Thiede, T. Bochtler, J.G. Okun, M. Saadati, A. Benner, S. Pusch, G. Ehninger, M. Schaich, A.D. Ho, A. von Deimling, A. Krämer and C E. Heilig |
| 264 | 1 | |c 2016 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published: 19 November 2015 | ||
| 500 | |a Gesehen am 29.07.2020 | ||
| 520 | |a Mutations in isocitrate dehydrogenases (IDHs) 1 and 2 frequently occur in acute myeloid leukemia (AML) and result in the production of the oncometabolite d-2-hydroxyglutarate (D2HG). D2HG has been shown to promote leukemogenesis even in the absence of mutated IDH, but the prognostic significance of pretreatment serum D2HG levels in patients with IDH-mutated AML is unclear. We measured D2HG serum levels in 84 patients with IDH-mutated AML treated in the prospective, randomized multicenter AML2003 trial of the German Study Alliance Leukemia. Multivariate Cox regression showed D2HG levels to negatively impact on event-free survival (EFS) as a continuous variable in the entire IDHmut cohort (P=0.04), with no effect on overall survival (OS). In a subgroup analysis, the negative impact of D2HG on EFS was found to be restricted to patients with mutations in IDH1 (P=0.003), adjusted for age, leukocyte count, serum lactate dehydrogenase and European LeukemiaNet risk score. We thus conclude that pretreatment D2HG serum levels may yield prognostic information in patients with IDH1-mutated, but not in IDH2-mutated AML, possibly due to different subcellular localizations of IDH1 and IDH2. | ||
| 534 | |c 2015 | ||
| 700 | 1 | |a Bochtler, Tilmann |d 1975- |e VerfasserIn |0 (DE-588)128398957 |0 (DE-627)372639925 |0 (DE-576)187323909 |4 aut | |
| 700 | 1 | |a Okun, Jürgen G. |d 1968- |e VerfasserIn |0 (DE-588)121578232 |0 (DE-627)705551415 |0 (DE-576)292781296 |4 aut | |
| 700 | 1 | |a Pusch, Stefan |d 1979- |e VerfasserIn |0 (DE-588)137014155 |0 (DE-627)58945224X |0 (DE-576)30150623X |4 aut | |
| 700 | 1 | |a Ho, Anthony Dick |d 1948- |e VerfasserIn |0 (DE-588)108692477 |0 (DE-627)504904205 |0 (DE-576)19010466X |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Krämer, Alwin |e VerfasserIn |0 (DE-588)1067780025 |0 (DE-627)819183431 |0 (DE-576)426900820 |4 aut | |
| 700 | 1 | |a Heilig, Christoph E. |d 1981- |e VerfasserIn |0 (DE-588)141951141 |0 (DE-627)632539798 |0 (DE-576)325796440 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia |d London : Springer Nature, 1997 |g 30(2016), 4, Seite 782-788 |h Online-Ressource |w (DE-627)32046699X |w (DE-600)2008023-2 |w (DE-576)094139733 |x 1476-5551 |7 nnas |a Pretreatment d -2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia |
| 773 | 1 | 8 | |g volume:30 |g year:2016 |g number:4 |g pages:782-788 |g extent:7 |a Pretreatment d -2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia |
| 856 | 4 | 0 | |u https://doi.org/10.1038/leu.2015.317 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/leu2015317 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200729 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 141951141 |a Heilig, Christoph E. |m 141951141:Heilig, Christoph E. |d 910000 |e 910000PH141951141 |k 0/910000/ |p 13 |y j | ||
| 998 | |g 1067780025 |a Krämer, Alwin |m 1067780025:Krämer, Alwin |d 910000 |d 910100 |e 910000PK1067780025 |e 910100PK1067780025 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 910000 |d 912000 |e 910000PD103034115X |e 912000PD103034115X |k 0/910000/ |k 1/910000/912000/ |p 11 | ||
| 998 | |g 108692477 |a Ho, Anthony Dick |m 108692477:Ho, Anthony Dick |d 910000 |d 910100 |e 910000PH108692477 |e 910100PH108692477 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 137014155 |a Pusch, Stefan |m 137014155:Pusch, Stefan |p 7 | ||
| 998 | |g 121578232 |a Okun, Jürgen G. |m 121578232:Okun, Jürgen G. |d 910000 |d 910500 |e 910000PO121578232 |e 910500PO121578232 |k 0/910000/ |k 1/910000/910500/ |p 4 | ||
| 998 | |g 128398957 |a Bochtler, Tilmann |m 128398957:Bochtler, Tilmann |p 3 | ||
| 998 | |g 133843173 |a Balß, Jörg |m 133843173:Balß, Jörg |p 1 |x j | ||
| 999 | |a KXP-PPN1725851164 |e 3731945851 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Pretreatment d -2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia","title_sort":"Pretreatment d -2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia"}],"physDesc":[{"extent":"7 S."}],"relHost":[{"part":{"extent":"7","issue":"4","pages":"782-788","year":"2016","volume":"30","text":"30(2016), 4, Seite 782-788"},"title":[{"title":"Leukemia","subtitle":"normal and malignant hemopoiesis ; a peer-reviewed journal","title_sort":"Leukemia"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"zdb":["2008023-2"],"eki":["32046699X"],"issn":["1476-5551"]},"recId":"32046699X","origin":[{"publisher":"Springer Nature ; Stockton Press ; Nature Publ. Group","dateIssuedDisp":"1997-","publisherPlace":"London ; Basingstoke [u.a.] ; Basingstoke","dateIssuedKey":"1997"}],"disp":"Pretreatment d -2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemiaLeukemia","language":["eng"],"note":["Gesehen am 15.03.04"],"pubHistory":["Nachgewiesen 11.1997 -"]}],"person":[{"given":"Jörg","family":"Balß","role":"aut","display":"Balß, Jörg"},{"given":"Tilmann","family":"Bochtler","role":"aut","display":"Bochtler, Tilmann"},{"family":"Okun","role":"aut","display":"Okun, Jürgen G.","given":"Jürgen G."},{"given":"Stefan","role":"aut","family":"Pusch","display":"Pusch, Stefan"},{"given":"Anthony Dick","display":"Ho, Anthony Dick","role":"aut","family":"Ho"},{"given":"Andreas von","display":"Deimling, Andreas von","family":"Deimling","role":"aut"},{"family":"Krämer","role":"aut","display":"Krämer, Alwin","given":"Alwin"},{"given":"Christoph E.","family":"Heilig","role":"aut","display":"Heilig, Christoph E."}],"language":["eng"],"note":["Published: 19 November 2015","Gesehen am 29.07.2020"],"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"2016"}],"name":{"displayForm":["J. Balss, C. Thiede, T. Bochtler, J.G. Okun, M. Saadati, A. Benner, S. Pusch, G. Ehninger, M. Schaich, A.D. Ho, A. von Deimling, A. Krämer and C E. Heilig"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1725851164","id":{"doi":["10.1038/leu.2015.317"],"eki":["1725851164"]}} | ||
| SRT | |a BALSSJOERGPRETREATME2016 | ||