Direct UV-induced functionalization of surface hydroxy groups by thiol-ol chemistry
A novel UV-initiated surface modification method for the direct functionalization of surface hydroxy groups with thiol-containing molecules (termed “thiol-ol” modification) is described. This method is based on the oxidative conjugation of thiols to hydroxy groups. We demonstrate that different thio...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 5, 2014
|
| In: |
Angewandte Chemie. International edition
Year: 2014, Jahrgang: 53, Heft: 15, Pages: 3835-3839 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201310692 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/anie.201310692 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201310692 
|
| Verfasserangaben: | Linxian Li, Junsheng Li, Xin Du, Alexander Welle, Michael Grunze, Oliver Trapp, and Pavel A. Levkin |
| Zusammenfassung: | A novel UV-initiated surface modification method for the direct functionalization of surface hydroxy groups with thiol-containing molecules (termed “thiol-ol” modification) is described. This method is based on the oxidative conjugation of thiols to hydroxy groups. We demonstrate that different thiol-containing molecules, such as fluorophores, thiol-terminated poly(ethylene glycol) (PEG-SH), and a cysteine-containing peptide, can be attached onto the surface of porous poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate). Direct functionalization of other hydroxy-group-bearing surfaces, fabrication of micropatterns, and double patterning have been also demonstrated using the thiol-ol method. |
|---|---|
| Beschreibung: | Gesehen am 29.07.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201310692 |