Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain
Endoplasmic reticulum (ER) stress, defective autophagy and genomic instability in the central nervous system are often associated with severe developmental defects and neurodegeneration. Here, we reveal the role played by Rint1 in these different biological pathways to ensure normal development of t...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
|
| In: |
Cell death and differentiation
Year: 2015, Volume: 23, Issue: 3, Pages: 454-468 |
| ISSN: | 1476-5403 |
| DOI: | 10.1038/cdd.2015.113 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/cdd.2015.113 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072440/ 
|
| Author Notes: | P. Grigaravicius, E. Kaminska, C.A. Hübner, P.J. McKinnon, A. von Deimling and P.-O. Frappart |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1726238652 | ||
| 003 | DE-627 | ||
| 005 | 20220818170127.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200805r20162015xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/cdd.2015.113 |2 doi | |
| 035 | |a (DE-627)1726238652 | ||
| 035 | |a (DE-599)KXP1726238652 | ||
| 035 | |a (OCoLC)1341348884 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Grigaravičius, Paulius |d 1979- |e VerfasserIn |0 (DE-588)139260145 |0 (DE-627)703268384 |0 (DE-576)310931428 |4 aut | |
| 245 | 1 | 0 | |a Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain |c P. Grigaravicius, E. Kaminska, C.A. Hübner, P.J. McKinnon, A. von Deimling and P.-O. Frappart |
| 264 | 1 | |c 2016 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online 18 September 2015 | ||
| 500 | |a Gesehen am 05.08.2020 | ||
| 520 | |a Endoplasmic reticulum (ER) stress, defective autophagy and genomic instability in the central nervous system are often associated with severe developmental defects and neurodegeneration. Here, we reveal the role played by Rint1 in these different biological pathways to ensure normal development of the central nervous system and to prevent neurodegeneration. We found that inactivation of Rint1 in neuroprogenitors led to death at birth. Depletion of Rint1 caused genomic instability due to chromosome fusion in dividing cells. Furthermore, Rint1 deletion in developing brain promotes the disruption of ER and Cis/Trans Golgi homeostasis in neurons, followed by ER-stress increase. Interestingly, Rint1 deficiency was also associated with the inhibition of the autophagosome clearance. Altogether, our findings highlight the crucial roles of Rint1 in vivo in genomic stability maintenance, as well as in prevention of ER stress and autophagy. | ||
| 534 | |c 2015 | ||
| 700 | 1 | |a Kamińska, Ewa |e VerfasserIn |0 (DE-588)1089079699 |0 (DE-627)850982693 |0 (DE-576)459403761 |4 aut | |
| 700 | 1 | |a Hübner, C A |e VerfasserIn |4 aut | |
| 700 | 1 | |a McKinnon, P J |e VerfasserIn |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Frappart, Pierre-Olivier |e VerfasserIn |0 (DE-588)1211045137 |0 (DE-627)1698915055 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell death and differentiation |d [London] : Springer Nature, 1997 |g 23(2016), 3, Seite 454-468 |h Online-Ressource |w (DE-627)306351226 |w (DE-600)1496681-5 |w (DE-576)104558512 |x 1476-5403 |7 nnas |a Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain |
| 773 | 1 | 8 | |g volume:23 |g year:2016 |g number:3 |g pages:454-468 |g extent:15 |a Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain |
| 856 | 4 | 0 | |u https://doi.org/10.1038/cdd.2015.113 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072440/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200805 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1211045137 |a Frappart, Pierre-Olivier |m 1211045137:Frappart, Pierre-Olivier |d 50000 |e 50000PF1211045137 |k 0/50000/ |p 6 |y j | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 60000 |d 63400 |e 60000PD103034115X |e 63400PD103034115X |k 0/60000/ |k 1/60000/63400/ |p 5 | ||
| 998 | |g 1089079699 |a Kamińska, Ewa |m 1089079699:Kamińska, Ewa |d 140000 |e 140000PK1089079699 |k 0/140000/ |p 2 | ||
| 998 | |g 139260145 |a Grigaravičius, Paulius |m 139260145:Grigaravičius, Paulius |p 1 |x j | ||
| 999 | |a KXP-PPN1726238652 |e 3735652646 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"2016"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"name":{"displayForm":["P. Grigaravicius, E. Kaminska, C.A. Hübner, P.J. McKinnon, A. von Deimling and P.-O. Frappart"]},"person":[{"display":"Grigaravičius, Paulius","role":"aut","given":"Paulius","roleDisplay":"VerfasserIn","family":"Grigaravičius"},{"given":"Ewa","role":"aut","display":"Kamińska, Ewa","family":"Kamińska","roleDisplay":"VerfasserIn"},{"family":"Hübner","roleDisplay":"VerfasserIn","given":"C A","display":"Hübner, C A","role":"aut"},{"roleDisplay":"VerfasserIn","family":"McKinnon","role":"aut","display":"McKinnon, P J","given":"P J"},{"family":"Deimling","roleDisplay":"VerfasserIn","given":"Andreas von","display":"Deimling, Andreas von","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Frappart","given":"Pierre-Olivier","role":"aut","display":"Frappart, Pierre-Olivier"}],"physDesc":[{"extent":"15 S."}],"relHost":[{"part":{"volume":"23","issue":"3","text":"23(2016), 3, Seite 454-468","pages":"454-468","extent":"15","year":"2016"},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2016","publisherPlace":"[London] ; London ; Houndmills, Basingstoke","dateIssuedDisp":"2016-","publisher":"Springer Nature ; Macmillan ; Nature Publishing Group"}],"id":{"zdb":["1496681-5"],"eki":["306351226"],"issn":["1476-5403"]},"title":[{"title":"Cell death and differentiation","title_sort":"Cell death and differentiation"}],"note":["Gesehen am 17.07.24"],"disp":"Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brainCell death and differentiation","pubHistory":["Nachgewiesen 4.1997 -"],"recId":"306351226"}],"recId":"1726238652","title":[{"title_sort":"Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain","title":"Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain"}],"id":{"doi":["10.1038/cdd.2015.113"],"eki":["1726238652"]},"note":["Published online 18 September 2015","Gesehen am 05.08.2020"]} | ||
| SRT | |a GRIGARAVICRINT1INACT2016 | ||