Laparoscopic mesh-augmented hiatoplasty with cardiophrenicopexy versus laparoscopic Nissen Fundoplication for the treatment of gastroesophageal reflux disease: A Double-center Randomized Controlled Trial

Objective: - Laparoscopic mesh-augmented hiatoplasty with cardiophrenicopexy (LMAH-C) might represent an alternative treatment of gastroesophageal reflux disease (GERD) and may provide durable reflux control without fundoplication. The expected benefit is the prevention of fundoplication-re...

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Bibliographische Detailangaben
Hauptverfasser: Müller, Beat P. (VerfasserIn) , Linke, Georg R. (VerfasserIn) , Senft, Jonas (VerfasserIn) , Achtstätter, Lena Verena (VerfasserIn) , Müller, Philip C. (VerfasserIn) , Diener, Markus K. (VerfasserIn) , Fischer, Lars (VerfasserIn) , Büchler, Markus W. (VerfasserIn)
Dokumenttyp: Article (Journal) Konferenzschrift
Sprache:Englisch
Veröffentlicht: 2015
In: Annals of surgery
Year: 2015, Jahrgang: 262, Heft: 5, Pages: 721-727
ISSN:1528-1140
DOI:10.1097/SLA.0000000000001444
Online-Zugang:Verlag, Volltext: https://doi.org/10.1097/SLA.0000000000001444
Verlag, Volltext: https://journals.lww.com/annalsofsurgery/Fulltext/2015/11000/Laparoscopic_Mesh_augmented_Hiatoplasty_With.4.aspx
Volltext
Verfasserangaben:Beat P. Müller-Stich, Georg R. Linke, Jonas Senft, Verena Achtstätter, Philip C. Müller, Markus K. Diener, Rene Warschkow, Francesco Marra, Bruno M. Schmied, Jan Borovicka, Lars Fischer, Andreas Zerz, Carsten N. Gutt, and Markus W. Büchler

MARC

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520 |a Objective: - Laparoscopic mesh-augmented hiatoplasty with cardiophrenicopexy (LMAH-C) might represent an alternative treatment of gastroesophageal reflux disease (GERD) and may provide durable reflux control without fundoplication. The expected benefit is the prevention of fundoplication-related side effects. Aim of the present trial was to compare LMAH-C with laparoscopic Nissen fundoplication (LNF) in patients with GERD. - Methods: - In a double-center randomized controlled trial (RCT) patients with proven GERD were eligible and assigned by central randomization to either LMAH-C (n = 46) or LNF (n = 44). The indigestion subscore of the Gastrointestinal Symptom Rating Scale questionnaire (GSRS) indicating gas-related symptoms as possible side effects of LNF was the primary endpoint. Secondary endpoints comprised pH testing and endoscopy and other symptoms measured by the GSRS, dysphagia, and the Gastrointestinal Quality of Life Index. The follow-up period was 36 months. - Results: - Indigestion subscore (LMAH-C 2.9 ± 1.5 vs LNF 3.7 ± 1.6; P = 0.031) but not dysphagia (2.8 ± 1.9 vs 2.3 ± 1.7; P = 0.302) and quality of life (106.9 ± 25.5 vs 105.8 ± 24.9; P = 0.838) differed between the groups at 36 months postoperatively. Although the reflux subscore improved in both groups, it was worse in LMAH-C patients (2.5 ± 1.6 vs 1.6 ± 1.0; P = 0.004) corresponding to a treatment failure of 77.3% in LMAH-C patients and of 34.1% in LNF patients (P < 0.001). - Conclusions: - LNF is more effective in the treatment of GERD than LMAH-C. Procedure-related side effects seem to exist but do not affect the quality of life. Laparoscopic fundoplication therefore remains the standard surgical treatment for GERD. 
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