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Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells

U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate with detectable rhythmic transcript levels. L...

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Bibliographic Details
Main Authors: Hoffmann, Julia (Author) , Shostak, Anton (Author) , Fischer, Tamás (Author) , Brunner, Michael (Author)
Format: Article (Journal)
Language:English
Published: July 9, 2014
In: PLOS ONE
Year: 2014, Volume: 9, Issue: 7
ISSN:1932-6203
DOI:10.1371/journal.pone.0102238
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0102238
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102238
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Author Notes:Julia Hoffmann, Laura Symul, Anton Shostak, Tamás Fischer, Felix Naef, Michael Brunner

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