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A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells

Cancer cells in the advanced stage show aberrant antioxidant capacity to detoxify excessive ROS resulting in the compensation for intrinsic oxidative stress and therapeutic resistance. PDAC is one of the most lethal cancers and often associated with a high accumulation of ROS. Recent studies identif...

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Bibliographische Detailangaben
Hauptverfasser: Cheng, Xinlai (VerfasserIn) , Holenya, Pavlo (VerfasserIn) , Can, Suzan (VerfasserIn) , Alborzinia, Hamed (VerfasserIn) , Rubbiani, Riccardo (VerfasserIn) , Ott, Ingo (VerfasserIn) , Wölfl, Stefan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [2014]
In: Molecular cancer
Year: 2014, Jahrgang: 13, Heft: 1
ISSN:1476-4598
DOI:10.1186/1476-4598-13-221
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1476-4598-13-221
Volltext
Verfasserangaben:Xinlai Cheng, Pavlo Holenya, Suzan Can, Hamed Alborzinia, Riccardo Rubbiani, Ingo Ott and Stefan Wölfl
Beschreibung
Zusammenfassung:Cancer cells in the advanced stage show aberrant antioxidant capacity to detoxify excessive ROS resulting in the compensation for intrinsic oxidative stress and therapeutic resistance. PDAC is one of the most lethal cancers and often associated with a high accumulation of ROS. Recent studies identified gold(I) NHC complexes as potent TrxR inhibitors suppressing cell growth in a wide spectrum of human malignant cell lines at the low micromolar concentration. However, the mechanism of action is not completely elucidated yet.
Beschreibung:Autor Pavlo Holenya falsch als "Palvo Holenya" angegeben
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Beschreibung:Online Resource
ISSN:1476-4598
DOI:10.1186/1476-4598-13-221

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