Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis
Communication by means of diffusible signaling molecules facilitates higher-level organization of cellular populations. Gram-positive bacteria frequently use signaling peptides, which are either detected at the cell surface or ‘probed’ by intracellular receptors after being pumped into the cytoplasm...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
04 March 2020
|
| In: |
Nature Communications
Year: 2020, Volume: 11 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-14840-w |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-14840-w Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-14840-w 
|
| Author Notes: | Heiko Babel, Pablo Naranjo-Meneses, Stephanie Trauth, Sonja Schulmeister, Gabriele Malengo, Victor Sourjik & Ilka B. Bischofs |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1726684792 | ||
| 003 | DE-627 | ||
| 005 | 20220818172020.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200810s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-020-14840-w |2 doi | |
| 035 | |a (DE-627)1726684792 | ||
| 035 | |a (DE-599)KXP1726684792 | ||
| 035 | |a (OCoLC)1341352097 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Babel, Heiko |e VerfasserIn |0 (DE-588)1101374233 |0 (DE-627)859693198 |0 (DE-576)469869666 |4 aut | |
| 245 | 1 | 0 | |a Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis |c Heiko Babel, Pablo Naranjo-Meneses, Stephanie Trauth, Sonja Schulmeister, Gabriele Malengo, Victor Sourjik & Ilka B. Bischofs |
| 264 | 1 | |c 04 March 2020 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.08.2020 | ||
| 520 | |a Communication by means of diffusible signaling molecules facilitates higher-level organization of cellular populations. Gram-positive bacteria frequently use signaling peptides, which are either detected at the cell surface or ‘probed’ by intracellular receptors after being pumped into the cytoplasm. While the former type is used to monitor cell density, the functions of pump-probe networks are less clear. Here we show that pump-probe networks can, in principle, perform different tasks and mediate quorum-sensing, chronometric and ratiometric control. We characterize the properties of the prototypical PhrA-RapA system in Bacillus subtilis using FRET. We find that changes in extracellular PhrA concentrations are tracked rather poorly; instead, cells accumulate and strongly amplify the signal in a dose-dependent manner. This suggests that the PhrA-RapA system, and others like it, have evolved to sense changes in the composition of heterogeneous populations and infer the fraction of signal-producing cells in a mixed population to coordinate cellular behaviors. | ||
| 700 | 1 | |a Naranjo-Meneses, Pablo |e VerfasserIn |0 (DE-588)1215511299 |0 (DE-627)1726686086 |4 aut | |
| 700 | 1 | |a Trauth, Stephanie |e VerfasserIn |0 (DE-588)1214674461 |0 (DE-627)1725700026 |4 aut | |
| 700 | 1 | |a Schulmeister, Sonja |e VerfasserIn |0 (DE-588)1020550082 |0 (DE-627)691257434 |0 (DE-576)360687458 |4 aut | |
| 700 | 1 | |a Malengo, Gabriele |e VerfasserIn |0 (DE-588)1133042562 |0 (DE-627)888189443 |0 (DE-576)489074626 |4 aut | |
| 700 | 1 | |a Sourjik, Victor |d 1970- |e VerfasserIn |0 (DE-588)1020549998 |0 (DE-627)69125737X |0 (DE-576)360687725 |4 aut | |
| 700 | 1 | |a Bischofs-Pfeifer, Ilka |d 1976- |e VerfasserIn |0 (DE-588)12975580X |0 (DE-627)479157774 |0 (DE-576)297820370 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 11(2020) Artikel-Nummer 1176, 13 Seiten |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis |
| 773 | 1 | 8 | |g volume:11 |g year:2020 |g extent:13 |a Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-020-14840-w |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-020-14840-w |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200810 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 12975580X |a Bischofs-Pfeifer, Ilka |m 12975580X:Bischofs-Pfeifer, Ilka |d 700000 |d 716000 |e 700000PB12975580X |e 716000PB12975580X |k 0/700000/ |k 1/700000/716000/ |p 7 |y j | ||
| 998 | |g 1215511299 |a Naranjo-Meneses, Pablo |m 1215511299:Naranjo-Meneses, Pablo |d 700000 |d 706000 |e 700000PN1215511299 |e 706000PN1215511299 |k 0/700000/ |k 1/700000/706000/ |p 2 | ||
| 999 | |a KXP-PPN1726684792 |e 3737252920 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"1726684792","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 10.08.2020"],"title":[{"title_sort":"Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis","title":"Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis"}],"person":[{"family":"Babel","given":"Heiko","display":"Babel, Heiko","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Naranjo-Meneses, Pablo","roleDisplay":"VerfasserIn","given":"Pablo","family":"Naranjo-Meneses"},{"role":"aut","display":"Trauth, Stephanie","roleDisplay":"VerfasserIn","given":"Stephanie","family":"Trauth"},{"given":"Sonja","family":"Schulmeister","role":"aut","display":"Schulmeister, Sonja","roleDisplay":"VerfasserIn"},{"given":"Gabriele","family":"Malengo","role":"aut","roleDisplay":"VerfasserIn","display":"Malengo, Gabriele"},{"family":"Sourjik","given":"Victor","display":"Sourjik, Victor","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Bischofs-Pfeifer, Ilka","roleDisplay":"VerfasserIn","role":"aut","family":"Bischofs-Pfeifer","given":"Ilka"}],"relHost":[{"recId":"626457688","language":["eng"],"note":["Gesehen am 13.06.24"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilisNature Communications","part":{"extent":"13","volume":"11","text":"11(2020) Artikel-Nummer 1176, 13 Seiten","year":"2020"},"pubHistory":["2010-"],"title":[{"title":"Nature Communications","title_sort":"Nature Communications"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2553671-0"],"eki":["626457688"],"issn":["2041-1723"]},"origin":[{"publisher":"Springer Nature ; Nature Publishing Group UK","dateIssuedDisp":"[2010]-","publisherPlace":"[London] ; [London]"}]}],"physDesc":[{"extent":"13 S."}],"id":{"eki":["1726684792"],"doi":["10.1038/s41467-020-14840-w"]},"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"04 March 2020"}],"name":{"displayForm":["Heiko Babel, Pablo Naranjo-Meneses, Stephanie Trauth, Sonja Schulmeister, Gabriele Malengo, Victor Sourjik & Ilka B. Bischofs"]}} | ||
| SRT | |a BABELHEIKORATIOMETRI0420 | ||