Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes
Matrix-Liposomes (MLs) are a very promising solid oral drug delivery system; however, data on their interaction with biological membranes are not available. Here, we describe the quality of MLs manufactured by dual centrifugation. MLs were prepared with a Z-average range of 139 to 160nm and a PDI of...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
06 June 2020
|
| In: |
European journal of pharmaceutics and biopharmaceutics
Year: 2020, Jahrgang: 153, Pages: 158-167 |
| ISSN: | 1873-3441 |
| DOI: | 10.1016/j.ejpb.2020.06.001 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejpb.2020.06.001 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0939641120301600 
|
| Verfasserangaben: | Michael Binnefeld, Sandra Fritz, Viktor Balzer, Veronika Skalická, Dominik Witzigmann, Hans-Ulrich Kauczor, Gert Fricker, Johanna J. Salomon |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1727012712 | ||
| 003 | DE-627 | ||
| 005 | 20230427022416.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200813s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejpb.2020.06.001 |2 doi | |
| 035 | |a (DE-627)1727012712 | ||
| 035 | |a (DE-599)KXP1727012712 | ||
| 035 | |a (OCoLC)1341355369 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Binnefeld, Michael |d 1988- |e VerfasserIn |0 (DE-588)1215867018 |0 (DE-627)1727013743 |4 aut | |
| 245 | 1 | 0 | |a Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes |c Michael Binnefeld, Sandra Fritz, Viktor Balzer, Veronika Skalická, Dominik Witzigmann, Hans-Ulrich Kauczor, Gert Fricker, Johanna J. Salomon |
| 264 | 1 | |c 06 June 2020 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 13.08.2020 | ||
| 520 | |a Matrix-Liposomes (MLs) are a very promising solid oral drug delivery system; however, data on their interaction with biological membranes are not available. Here, we describe the quality of MLs manufactured by dual centrifugation. MLs were prepared with a Z-average range of 139 to 160nm and a PDI of 0.18 to 0.25. To investigate the effect of MLs on intestinal tissue (with and without mucolytic treatment), we then established an ex vivo rat intestine model. The integrity of the epithelial membranes of rat intestine was not affected by the incubation with MLs without or with pre-mucolytic treatment. Tissue samples were also analysed for changes in P-glycoprotein (P-gp) expression and function. The net secretion of the P-gp substrate Rh123 across the rat duodenum was increased in the presence of MLs. To summarize, MLs do not affect intestinal epithelial integrity, although they impact Rh123 secretion. In future, these novel MLs have to be further evaluated for proficient intestinal drug delivery. | ||
| 650 | 4 | |a Drug transporters | |
| 650 | 4 | |a Dual centrifugation | |
| 650 | 4 | |a Intestine | |
| 650 | 4 | |a Liposomes | |
| 650 | 4 | |a Oral peptide drug delivery | |
| 650 | 4 | |a Ussing Chamber | |
| 700 | 1 | |a Fritz, Sandra |e VerfasserIn |0 (DE-588)1215867468 |0 (DE-627)1727015096 |4 aut | |
| 700 | 1 | |a Balzer, Viktor |d 1989- |e VerfasserIn |0 (DE-588)1215867778 |0 (DE-627)1727016343 |4 aut | |
| 700 | 1 | |a Skalická, Veronika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Witzigmann, Dominik |e VerfasserIn |0 (DE-588)1198953012 |0 (DE-627)1681160722 |4 aut | |
| 700 | 1 | |a Kauczor, Hans-Ulrich |d 1962- |e VerfasserIn |0 (DE-588)139267123 |0 (DE-627)70327113X |0 (DE-576)310955327 |4 aut | |
| 700 | 1 | |a Fricker, Gert |d 1956- |e VerfasserIn |0 (DE-588)1042227675 |0 (DE-627)768469465 |0 (DE-576)393783464 |4 aut | |
| 700 | 1 | |a Salomon, Johanna J. |e VerfasserIn |0 (DE-588)1138814636 |0 (DE-627)896409104 |0 (DE-576)492719918 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of pharmaceutics and biopharmaceutics |d New York, NY [u.a.] : Elsevier, 1997 |g 153(2020), Seite 158-167 |h Online-Ressource |w (DE-627)300897324 |w (DE-600)1483524-1 |w (DE-576)259270822 |x 1873-3441 |7 nnas |a Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes |
| 773 | 1 | 8 | |g volume:153 |g year:2020 |g pages:158-167 |g extent:10 |a Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ejpb.2020.06.001 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0939641120301600 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200813 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1138814636 |a Salomon, Johanna J. |m 1138814636:Salomon, Johanna J. |d 910000 |d 910500 |e 910000PS1138814636 |e 910500PS1138814636 |k 0/910000/ |k 1/910000/910500/ |p 8 |y j | ||
| 998 | |g 1042227675 |a Fricker, Gert |m 1042227675:Fricker, Gert |d 160000 |d 160100 |e 160000PF1042227675 |e 160100PF1042227675 |k 0/160000/ |k 1/160000/160100/ |p 7 | ||
| 998 | |g 139267123 |a Kauczor, Hans-Ulrich |m 139267123:Kauczor, Hans-Ulrich |d 910000 |d 911400 |e 910000PK139267123 |e 911400PK139267123 |k 0/910000/ |k 1/910000/911400/ |p 6 | ||
| 998 | |g 1215867778 |a Balzer, Viktor |m 1215867778:Balzer, Viktor |d 160000 |d 160100 |e 160000PB1215867778 |e 160100PB1215867778 |k 0/160000/ |k 1/160000/160100/ |p 3 | ||
| 999 | |a KXP-PPN1727012712 |e 3739339500 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"10 S."}],"recId":"1727012712","origin":[{"dateIssuedDisp":"06 June 2020","dateIssuedKey":"2020"}],"person":[{"display":"Binnefeld, Michael","role":"aut","given":"Michael","family":"Binnefeld"},{"display":"Fritz, Sandra","given":"Sandra","role":"aut","family":"Fritz"},{"role":"aut","given":"Viktor","family":"Balzer","display":"Balzer, Viktor"},{"display":"Skalická, Veronika","family":"Skalická","role":"aut","given":"Veronika"},{"role":"aut","given":"Dominik","family":"Witzigmann","display":"Witzigmann, Dominik"},{"display":"Kauczor, Hans-Ulrich","given":"Hans-Ulrich","role":"aut","family":"Kauczor"},{"display":"Fricker, Gert","given":"Gert","role":"aut","family":"Fricker"},{"display":"Salomon, Johanna J.","given":"Johanna J.","role":"aut","family":"Salomon"}],"relHost":[{"part":{"pages":"158-167","year":"2020","text":"153(2020), Seite 158-167","volume":"153","extent":"10"},"id":{"eki":["300897324"],"issn":["1873-3441"],"zdb":["1483524-1"]},"titleAlt":[{"title":"EJPB"}],"pubHistory":["Nachgewiesen 43.1997 -"],"note":["Gesehen am 25.05.2020"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"title":[{"subtitle":"EJPB ; official journal of the International Association for Pharmaceutical Technology","title_sort":"European journal of pharmaceutics and biopharmaceutics","title":"European journal of pharmaceutics and biopharmaceutics"}],"origin":[{"publisher":"Elsevier","publisherPlace":"New York, NY [u.a.]","dateIssuedKey":"1997","dateIssuedDisp":"1997-"}],"disp":"Physicochemical and biopharmaceutical characterization of novel Matrix-LiposomesEuropean journal of pharmaceutics and biopharmaceutics","physDesc":[{"extent":"Online-Ressource"}],"recId":"300897324"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"note":["Gesehen am 13.08.2020"],"title":[{"title":"Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes","title_sort":"Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes"}],"name":{"displayForm":["Michael Binnefeld, Sandra Fritz, Viktor Balzer, Veronika Skalická, Dominik Witzigmann, Hans-Ulrich Kauczor, Gert Fricker, Johanna J. Salomon"]},"id":{"eki":["1727012712"],"doi":["10.1016/j.ejpb.2020.06.001"]}} | ||
| SRT | |a BINNEFELDMPHYSICOCHE0620 | ||