Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal®
Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior stability, has already been proved efficient in repairing corn...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05 May 2020
|
| In: |
Frontiers in endocrinology
Year: 2020, Jahrgang: 11 |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2020.00285 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fendo.2020.00285 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fendo.2020.00285/full 
|
| Verfasserangaben: | Adriana Di Benedetto, Francesca Posa, Mario Marazzi, Zamira Kalemaj, Roberta Grassi, Lorenzo Lo Muzio, Mariasevera Di Comite, Elisabetta Ada Cavalcanti-Adam, Felice Roberto Grassi and Giorgio Mori |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1727030869 | ||
| 003 | DE-627 | ||
| 005 | 20220818174623.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200813s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fendo.2020.00285 |2 doi | |
| 035 | |a (DE-627)1727030869 | ||
| 035 | |a (DE-599)KXP1727030869 | ||
| 035 | |a (OCoLC)1341355232 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Di Benedetto, Adriana |e VerfasserIn |0 (DE-588)1170842038 |0 (DE-627)1040137288 |0 (DE-576)512684251 |4 aut | |
| 245 | 1 | 0 | |a Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal® |c Adriana Di Benedetto, Francesca Posa, Mario Marazzi, Zamira Kalemaj, Roberta Grassi, Lorenzo Lo Muzio, Mariasevera Di Comite, Elisabetta Ada Cavalcanti-Adam, Felice Roberto Grassi and Giorgio Mori |
| 264 | 1 | |c 05 May 2020 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 13.08.2020 | ||
| 520 | |a Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior stability, has already been proved efficient in repairing corneal epithelial cells damaged by dry conditions in vitro. We investigated the regenerative potential of T-Lys in the hard tissues bone and cartilage. We have previously demonstrated that cells isolated from the tooth germ, Dental Bud Stem Cells (DBSCs), differentiate into osteoblast-like cells, representing a promising source of MSCs for bone regeneration. Herewith, we show that T-Lys treatment stimulates the expression of typical osteoblastic markers, such as Alkaline Phosphatase (ALP) and Osteopontin (OPN), determining a higher production of mineralized matrix nodules. In addition, we found that T-Lys treatment positively affects αVβ3 integrin expression, key integrin in the osteoblastic commitment, leading to the formation of focal adhesions (FAs). The efficacy of T-Lys was also tested on chondrogenic differentiation starting from human articular chondrocytes (HACs) resulting in an increase of differentiation markers and cell number. | ||
| 650 | 4 | |a Bone | |
| 650 | 4 | |a Cartilage | |
| 650 | 4 | |a Focal Adhesions | |
| 650 | 4 | |a Mesenchymal Stem Cells | |
| 650 | 4 | |a supramolecolar aggregate | |
| 650 | 4 | |a Tissue Regeneration | |
| 700 | 1 | |a Cavalcanti-Adam, Elisabetta A. |d 1972- |e VerfasserIn |0 (DE-588)1059179458 |0 (DE-627)798132256 |0 (DE-576)189133511 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in endocrinology |d Lausanne : Frontiers Research Foundation, 2010 |g 11(2020) Artikel-Nummer 285, 11 Seiten |h Online-Ressource |w (DE-627)645090948 |w (DE-600)2592084-4 |w (DE-576)336962975 |x 1664-2392 |7 nnas |a Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal® |
| 773 | 1 | 8 | |g volume:11 |g year:2020 |g extent:11 |a Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal® |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fendo.2020.00285 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fendo.2020.00285/full |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200813 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1059179458 |a Cavalcanti-Adam, Elisabetta A. |m 1059179458:Cavalcanti-Adam, Elisabetta A. |d 140000 |e 140000PC1059179458 |k 0/140000/ |p 8 | ||
| 999 | |a KXP-PPN1727030869 |e 3739378050 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 13.08.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1727030869","language":["eng"],"person":[{"display":"Di Benedetto, Adriana","roleDisplay":"VerfasserIn","role":"aut","family":"Di Benedetto","given":"Adriana"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Cavalcanti-Adam, Elisabetta A.","given":"Elisabetta A.","family":"Cavalcanti-Adam"}],"title":[{"title":"Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal®","title_sort":"Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal®"}],"physDesc":[{"extent":"11 S."}],"relHost":[{"title":[{"title":"Frontiers in endocrinology","title_sort":"Frontiers in endocrinology"}],"disp":"Osteogenic and chondrogenic potential of the supramolecular aggregate T-LysYal®Frontiers in endocrinology","note":["Gesehen am 12.12.19","Specialty sections: Bone Research; Cancer Endocrinology; Cellular Endocrinology; Diabetes; Endocrinology of Aging; Experimental Endocrinology; Genomic Endocrinology; Molecular and Structural Endocrinology; Neuroendocrine Science; Pediatric Endocrinology; Pituitary Endocrinology; Systems and Translational Endocrinology; Thyroid Endocrinology"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"645090948","language":["eng"],"pubHistory":["1.2010 -"],"titleAlt":[{"title":"Bone Research"},{"title":"Cancer Endocrinology"},{"title":"Cellular Endocrinology"},{"title":"Diabetes"},{"title":"Endocrinology of Aging"},{"title":"Experimental Endocrinology"},{"title":"Genomic Endocrinology"},{"title":"Molecular and Structural Endocrinology"},{"title":"Neuroendocrine Science"},{"title":"Pediatric Endocrinology"},{"title":"Pituitary Endocrinology"},{"title":"Systems and Translational Endocrinology"},{"title":"Thyroid Endocrinology"}],"part":{"year":"2020","extent":"11","text":"11(2020) Artikel-Nummer 285, 11 Seiten","volume":"11"},"origin":[{"publisher":"Frontiers Research Foundation","dateIssuedKey":"2010","dateIssuedDisp":"2010-","publisherPlace":"Lausanne"}],"id":{"issn":["1664-2392"],"eki":["645090948"],"zdb":["2592084-4"]},"physDesc":[{"extent":"Online-Ressource"}]}],"name":{"displayForm":["Adriana Di Benedetto, Francesca Posa, Mario Marazzi, Zamira Kalemaj, Roberta Grassi, Lorenzo Lo Muzio, Mariasevera Di Comite, Elisabetta Ada Cavalcanti-Adam, Felice Roberto Grassi and Giorgio Mori"]},"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"05 May 2020"}],"id":{"doi":["10.3389/fendo.2020.00285"],"eki":["1727030869"]}} | ||
| SRT | |a DIBENEDETTOSTEOGENIC0520 | ||