Recurrent miscarriages, innate immunity, and autoimmune reaction to chlamydial 60-kDa heat shock protein: is there an association?
Objective - To evaluate a potential association of immunity to the Chlamydia trachomatis 60kDa heat shock protein (ChlamHSP60) and recurrent miscarriages. - Design - Prospective study. - Setting - Outpatient miscarriage clinic of a university-based hospital. - Patient(s) - 120 asymptomatic women wit...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 26, 2014
|
| In: |
Fertility and sterility
Year: 2014, Jahrgang: 101, Heft: 6, Pages: 1675-1680 |
| ISSN: | 1556-5653 |
| DOI: | 10.1016/j.fertnstert.2014.02.048 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.fertnstert.2014.02.048 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0015028214002015 
|
| Verfasserangaben: | Waltraud Eggert-Kruse, MD, Sandra Scholz, MD, Michael Kirschfink, PhD, and Thomas Strowitzki, MD |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1727142322 | ||
| 003 | DE-627 | ||
| 005 | 20230427022506.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200817s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.fertnstert.2014.02.048 |2 doi | |
| 035 | |a (DE-627)1727142322 | ||
| 035 | |a (DE-599)KXP1727142322 | ||
| 035 | |a (OCoLC)1341355434 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Eggert-Kruse, Waltraud |e VerfasserIn |0 (DE-588)1077958110 |0 (DE-627)837790557 |0 (DE-576)169943186 |4 aut | |
| 245 | 1 | 0 | |a Recurrent miscarriages, innate immunity, and autoimmune reaction to chlamydial 60-kDa heat shock protein |b is there an association? |c Waltraud Eggert-Kruse, MD, Sandra Scholz, MD, Michael Kirschfink, PhD, and Thomas Strowitzki, MD |
| 264 | 1 | |c March 26, 2014 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.08.2020 | ||
| 520 | |a Objective - To evaluate a potential association of immunity to the Chlamydia trachomatis 60kDa heat shock protein (ChlamHSP60) and recurrent miscarriages. - Design - Prospective study. - Setting - Outpatient miscarriage clinic of a university-based hospital. - Patient(s) - 120 asymptomatic women with a history of recurrent miscarriages. - Intervention(s) - None. - Main Outcome Measure(s) - Determination of serum immunoglobulin G (IgG) antibodies (Ab) to ChlamHSP60 and human HSP60 and, in parallel, mannose-binding lectin (MBL) and the total hemolytic complement (CH50); medical history and clinical examination, including multiple relevant laboratory determinants. - Result(s) - ChlamHSP60 Ab were detected in 24 (20%) of 120 patients. Antibodies to human HSP60 were found in 19 (15.8%) of 120 patients, and more frequently in individuals who tested positive for ChlamHSP60. ChlamHSP60 were statistically significantly associated with antichlamydial IgG Ab. However, antibodies to ChlamHSP60 were not related to medical history, the number of abortions, or the time frame of fetal loss. ChlamHSP60 antibodies were not associated with the relevant variables of the coagulation cascade, a panel of autoimmune parameters including thyroid autoimmunity, deficiencies of the complement system (low MBL), or with antibodies to common infectious diseases. No statistically significant differences were was found when comparing the prevalence of ChlamHSP60 Ab in the study group with recurrent miscarriages and 90 controls (women attending for an annual pelvic examination). - Conclusion(s) - Immunity to ChlamHSP60 does not play a major role in the etiology of recurrent miscarriages. | ||
| 650 | 4 | |a Chlamydial 60kDa heat shock protein (Chlam HSP60) | |
| 650 | 4 | |a complement | |
| 650 | 4 | |a heat shock proteins (HSP) | |
| 650 | 4 | |a mannose-binding lectin (MBL) | |
| 650 | 4 | |a recurrent miscarriages | |
| 650 | 4 | |a sexually transmitted diseases (STD) | |
| 650 | 4 | |a subclinical infection/inflammation markers | |
| 700 | 1 | |a Scholz, Sandra |d 1979- |e VerfasserIn |0 (DE-588)1012118800 |0 (DE-627)661320529 |0 (DE-576)344955923 |4 aut | |
| 700 | 1 | |a Kirschfink, Michael |e VerfasserIn |0 (DE-588)120927152 |0 (DE-627)080974457 |0 (DE-576)292452411 |4 aut | |
| 700 | 1 | |a Strowitzki, Thomas |d 1959- |e VerfasserIn |0 (DE-588)118055917 |0 (DE-627)079216099 |0 (DE-576)17102141X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Fertility and sterility |d Amsterdam [u.a.] : Elsevier Science, 1950 |g 101(2014), 6, Seite 1675-1680 |h Online-Ressource |w (DE-627)306659492 |w (DE-600)1500469-7 |w (DE-576)121465454 |x 1556-5653 |7 nnas |a Recurrent miscarriages, innate immunity, and autoimmune reaction to chlamydial 60-kDa heat shock protein is there an association? |
| 773 | 1 | 8 | |g volume:101 |g year:2014 |g number:6 |g pages:1675-1680 |g extent:6 |a Recurrent miscarriages, innate immunity, and autoimmune reaction to chlamydial 60-kDa heat shock protein is there an association? |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.fertnstert.2014.02.048 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0015028214002015 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200817 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 118055917 |a Strowitzki, Thomas |m 118055917:Strowitzki, Thomas |d 910000 |d 910400 |e 910000PS118055917 |e 910400PS118055917 |k 0/910000/ |k 1/910000/910400/ |p 4 |y j | ||
| 998 | |g 120927152 |a Kirschfink, Michael |m 120927152:Kirschfink, Michael |d 910000 |d 911600 |e 910000PK120927152 |e 911600PK120927152 |k 0/910000/ |k 1/910000/911600/ |p 3 | ||
| 998 | |g 1012118800 |a Scholz, Sandra |m 1012118800:Scholz, Sandra |p 2 | ||
| 998 | |g 1077958110 |a Eggert-Kruse, Waltraud |m 1077958110:Eggert-Kruse, Waltraud |p 1 |x j | ||
| 999 | |a KXP-PPN1727142322 |e 3740475935 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Waltraud Eggert-Kruse, MD, Sandra Scholz, MD, Michael Kirschfink, PhD, and Thomas Strowitzki, MD"]},"physDesc":[{"extent":"6 S."}],"recId":"1727142322","relHost":[{"recId":"306659492","pubHistory":["1.1950 -"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1500469-7"],"eki":["306659492"],"issn":["1556-5653"]},"disp":"Recurrent miscarriages, innate immunity, and autoimmune reaction to chlamydial 60-kDa heat shock protein is there an association?Fertility and sterility","language":["eng"],"part":{"year":"2014","pages":"1675-1680","text":"101(2014), 6, Seite 1675-1680","extent":"6","volume":"101","issue":"6"},"note":["Gesehen am 26.01.24","Ungezählte Beil.: Supplement"],"origin":[{"dateIssuedDisp":"1950-","publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1950","publisher":"Elsevier Science"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title_sort":"Fertility and sterility","title":"Fertility and sterility"}]}],"id":{"doi":["10.1016/j.fertnstert.2014.02.048"],"eki":["1727142322"]},"person":[{"family":"Eggert-Kruse","display":"Eggert-Kruse, Waltraud","given":"Waltraud","role":"aut"},{"given":"Sandra","role":"aut","display":"Scholz, Sandra","family":"Scholz"},{"family":"Kirschfink","display":"Kirschfink, Michael","role":"aut","given":"Michael"},{"role":"aut","given":"Thomas","family":"Strowitzki","display":"Strowitzki, Thomas"}],"note":["Gesehen am 17.08.2020"],"title":[{"subtitle":"is there an association?","title_sort":"Recurrent miscarriages, innate immunity, and autoimmune reaction to chlamydial 60-kDa heat shock protein","title":"Recurrent miscarriages, innate immunity, and autoimmune reaction to chlamydial 60-kDa heat shock protein"}],"origin":[{"dateIssuedKey":"2014","dateIssuedDisp":"March 26, 2014"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"]} | ||
| SRT | |a EGGERTKRUSRECURRENTM2620 | ||