Candidate drugs against SARS-CoV-2 and COVID-19
Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 April 2020
|
| In: |
Pharmacological research
Year: 2020, Jahrgang: 157 |
| ISSN: | 1096-1186 |
| DOI: | 10.1016/j.phrs.2020.104859 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.phrs.2020.104859 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1043661820311671 
|
| Verfasserangaben: | Dwight L. McKee, Ariane Sternberg, Ulrike Stange, Stefan Laufer, Cord Naujokat |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1727146026 | ||
| 003 | DE-627 | ||
| 005 | 20230427022507.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200817s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.phrs.2020.104859 |2 doi | |
| 035 | |a (DE-627)1727146026 | ||
| 035 | |a (DE-599)KXP1727146026 | ||
| 035 | |a (OCoLC)1341355260 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a McKee, Dwight L. |e VerfasserIn |0 (DE-588)1111818665 |0 (DE-627)865926042 |0 (DE-576)476288614 |4 aut | |
| 245 | 1 | 0 | |a Candidate drugs against SARS-CoV-2 and COVID-19 |c Dwight L. McKee, Ariane Sternberg, Ulrike Stange, Stefan Laufer, Cord Naujokat |
| 264 | 1 | |c 29 April 2020 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.08.2020 | ||
| 520 | |a Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibit infection with and replication of SARS-CoV-2. Such drugs comprise inhibitors of TMPRSS2 serine protease and inhibitors of angiotensin-converting enzyme 2 (ACE2). Blockade of ACE2, the host cell receptor for the S protein of SARS-CoV-2 and inhibition of TMPRSS2, which is required for S protein priming may prevent cell entry of SARS-CoV-2. Further, chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may limit spread of SARS-CoV-2 and morbidity and mortality of COVID-19 pandemic. | ||
| 650 | 4 | |a Arbidol | |
| 650 | 4 | |a Camostat | |
| 650 | 4 | |a Chloroquine | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Drugs | |
| 650 | 4 | |a Favipiravir | |
| 650 | 4 | |a Lopinavir | |
| 650 | 4 | |a Phytochemicals | |
| 650 | 4 | |a Remdesivir | |
| 650 | 4 | |a Ritonavir | |
| 650 | 4 | |a SARS-CoV-2 | |
| 700 | 1 | |a Sternberg, Ariane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stange, Ulrike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Laufer, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Naujokat, Cord |d 1964- |e VerfasserIn |0 (DE-588)123190592 |0 (DE-627)082401616 |0 (DE-576)184229537 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pharmacological research |d [Amsterdam] : Elsevier, 1989 |g 157(2020) Artikel-Nummer 104859, 9 Seiten |h Online-Ressource |w (DE-627)268125872 |w (DE-600)1471456-5 |w (DE-576)259483761 |x 1096-1186 |7 nnas |a Candidate drugs against SARS-CoV-2 and COVID-19 |
| 773 | 1 | 8 | |g volume:157 |g year:2020 |g extent:9 |a Candidate drugs against SARS-CoV-2 and COVID-19 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.phrs.2020.104859 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1043661820311671 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200817 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 123190592 |a Naujokat, Cord |m 123190592:Naujokat, Cord |d 50000 |e 50000PN123190592 |k 0/50000/ |p 5 |y j | ||
| 999 | |a KXP-PPN1727146026 |e 3740484047 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 17.08.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1727146026","title":[{"title_sort":"Candidate drugs against SARS-CoV-2 and COVID-19","title":"Candidate drugs against SARS-CoV-2 and COVID-19"}],"person":[{"display":"McKee, Dwight L.","roleDisplay":"VerfasserIn","role":"aut","family":"McKee","given":"Dwight L."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Sternberg, Ariane","given":"Ariane","family":"Sternberg"},{"family":"Stange","given":"Ulrike","roleDisplay":"VerfasserIn","display":"Stange, Ulrike","role":"aut"},{"given":"Stefan","family":"Laufer","role":"aut","roleDisplay":"VerfasserIn","display":"Laufer, Stefan"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Naujokat, Cord","given":"Cord","family":"Naujokat"}],"physDesc":[{"extent":"9 S."}],"relHost":[{"title":[{"subtitle":"the official journal of the Italian Pharmacological Society","title":"Pharmacological research","title_sort":"Pharmacological research"}],"part":{"year":"2020","extent":"9","volume":"157","text":"157(2020) Artikel-Nummer 104859, 9 Seiten"},"pubHistory":["21.1989 -"],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Società Italiana di Farmacologia","role":"isb"}],"language":["eng"],"recId":"268125872","note":["Gesehen am 10.02.2020","Ungezählte Beil.: Supplement"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Candidate drugs against SARS-CoV-2 and COVID-19Pharmacological research","id":{"issn":["1096-1186"],"eki":["268125872"],"zdb":["1471456-5"]},"origin":[{"publisherPlace":"[Amsterdam] ; London","dateIssuedKey":"1989","publisher":"Elsevier ; Academic Press","dateIssuedDisp":"1989-"}],"physDesc":[{"extent":"Online-Ressource"}]}],"origin":[{"dateIssuedDisp":"29 April 2020","dateIssuedKey":"2020"}],"id":{"doi":["10.1016/j.phrs.2020.104859"],"eki":["1727146026"]},"name":{"displayForm":["Dwight L. McKee, Ariane Sternberg, Ulrike Stange, Stefan Laufer, Cord Naujokat"]}} | ||
| SRT | |a MCKEEDWIGHCANDIDATED2920 | ||