Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton
Chronic lymphocytic leukemia (CLL) is an incurable malignancy of mature B cells. One of the major challenges in treatment of CLL is the achievement of a complete remission to prevent relapse of disease originating from cells within lymphoid tissues and subsequent chemoresistance. In search for novel...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 January 2014
|
| In: |
Leukemia
Year: 2014, Jahrgang: 28, Heft: 6, Pages: 1289-1298 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/leu.2013.360 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/leu.2013.360 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/leu2013360 
|
| Verfasserangaben: | P.B. Knudsen, B. Hanna, S. Ohl, L. Sellner, T. Zenz, H. Döhner, S. Stilgenbauer, T.O. Larsen, P. Lichter and M. Seiffert |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1727161912 | ||
| 003 | DE-627 | ||
| 005 | 20230427022513.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200817s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/leu.2013.360 |2 doi | |
| 035 | |a (DE-627)1727161912 | ||
| 035 | |a (DE-599)KXP1727161912 | ||
| 035 | |a (OCoLC)1341355565 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Knudsen, Peter Boldsen |e VerfasserIn |0 (DE-588)1216064245 |0 (DE-627)1727163303 |4 aut | |
| 245 | 1 | 0 | |a Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton |c P.B. Knudsen, B. Hanna, S. Ohl, L. Sellner, T. Zenz, H. Döhner, S. Stilgenbauer, T.O. Larsen, P. Lichter and M. Seiffert |
| 264 | 1 | |c 10 January 2014 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.08.2020 | ||
| 520 | |a Chronic lymphocytic leukemia (CLL) is an incurable malignancy of mature B cells. One of the major challenges in treatment of CLL is the achievement of a complete remission to prevent relapse of disease originating from cells within lymphoid tissues and subsequent chemoresistance. In search for novel drugs that target CLL cells in protective microenvironments, we performed a fungal extract screen using cocultures of primary CLL cells with bone marrow-derived stromal cells. A secondary metabolite produced by Penicillium aquamarinium was identified as Chaetoglobosin A (ChA), a member of the cytochalasan family that showed preferential induction of apoptosis in CLL cells, even under culture conditions that mimic lymphoid tissues. In vitro testing of 89 CLL cases revealed effective targeting of CLL cells by ChA, independent of bad prognosis characteristics, like 17p deletion or TP53 mutation. To provide insight into its mechanism of action, we showed that ChA targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration. Our data further revealed that ChA prevents CLL cell activation and sensitizes them for treatment with PI3K and BTK inhibitors, suggesting this compound as a novel potential drug for CLL. | ||
| 700 | 1 | |a Hanna, Bola |e VerfasserIn |0 (DE-588)1113304316 |0 (DE-627)867170220 |0 (DE-576)476946662 |4 aut | |
| 700 | 1 | |a Ohl, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sellner, Leopold |d 1984- |e VerfasserIn |0 (DE-588)143493825 |0 (DE-627)646576704 |0 (DE-576)337362963 |4 aut | |
| 700 | 1 | |a Zenz, Thorsten |d 1970- |e VerfasserIn |0 (DE-588)114963738 |0 (DE-627)577184202 |0 (DE-576)180278266 |4 aut | |
| 700 | 1 | |a Döhner, H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stilgenbauer, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Larsen, T. O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lichter, Peter |d 1957- |e VerfasserIn |0 (DE-588)1096366282 |0 (DE-627)856749915 |0 (DE-576)468019049 |4 aut | |
| 700 | 1 | |a Seiffert, Moritz |d 1981- |e VerfasserIn |0 (DE-588)137207239 |0 (DE-627)591016257 |0 (DE-576)302814639 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia |d London : Springer Nature, 1997 |g 28(2014), 6, Seite 1289-1298 |h Online-Ressource |w (DE-627)32046699X |w (DE-600)2008023-2 |w (DE-576)094139733 |x 1476-5551 |7 nnas |a Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton |
| 773 | 1 | 8 | |g volume:28 |g year:2014 |g number:6 |g pages:1289-1298 |g extent:10 |a Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton |
| 856 | 4 | 0 | |u https://doi.org/10.1038/leu.2013.360 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/leu2013360 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200817 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 1096366282 |a Lichter, Peter |m 1096366282:Lichter, Peter |d 50000 |e 50000PL1096366282 |k 0/50000/ |p 9 | ||
| 998 | |g 114963738 |a Zenz, Thorsten |m 114963738:Zenz, Thorsten |p 5 | ||
| 998 | |g 143493825 |a Sellner, Leopold |m 143493825:Sellner, Leopold |d 910000 |d 910100 |e 910000PS143493825 |e 910100PS143493825 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 999 | |a KXP-PPN1727161912 |e 3740516143 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"10 S."}],"id":{"eki":["1727161912"],"doi":["10.1038/leu.2013.360"]},"title":[{"title_sort":"Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton","title":"Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2014","dateIssuedDisp":"10 January 2014"}],"relHost":[{"disp":"Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeletonLeukemia","type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"part":{"year":"2014","volume":"28","text":"28(2014), 6, Seite 1289-1298","pages":"1289-1298","extent":"10","issue":"6"},"pubHistory":["Nachgewiesen 11.1997 -"],"note":["Gesehen am 15.03.04"],"title":[{"title":"Leukemia","subtitle":"normal and malignant hemopoiesis ; a peer-reviewed journal","title_sort":"Leukemia"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1476-5551"],"eki":["32046699X"],"zdb":["2008023-2"]},"origin":[{"dateIssuedDisp":"1997-","publisher":"Springer Nature ; Stockton Press ; Nature Publ. Group","publisherPlace":"London ; Basingstoke [u.a.] ; Basingstoke","dateIssuedKey":"1997"}],"recId":"32046699X"}],"language":["eng"],"name":{"displayForm":["P.B. Knudsen, B. Hanna, S. Ohl, L. Sellner, T. Zenz, H. Döhner, S. Stilgenbauer, T.O. Larsen, P. Lichter and M. Seiffert"]},"note":["Gesehen am 17.08.2020"],"recId":"1727161912","person":[{"family":"Knudsen","role":"aut","given":"Peter Boldsen","display":"Knudsen, Peter Boldsen"},{"family":"Hanna","role":"aut","display":"Hanna, Bola","given":"Bola"},{"given":"S.","display":"Ohl, S.","family":"Ohl","role":"aut"},{"given":"Leopold","display":"Sellner, Leopold","family":"Sellner","role":"aut"},{"display":"Zenz, Thorsten","given":"Thorsten","family":"Zenz","role":"aut"},{"given":"H.","display":"Döhner, H.","role":"aut","family":"Döhner"},{"family":"Stilgenbauer","role":"aut","given":"S.","display":"Stilgenbauer, S."},{"display":"Larsen, T. O.","given":"T. O.","family":"Larsen","role":"aut"},{"role":"aut","family":"Lichter","display":"Lichter, Peter","given":"Peter"},{"given":"Moritz","display":"Seiffert, Moritz","role":"aut","family":"Seiffert"}]} | ||
| SRT | |a KNUDSENPETCHAETOGLOB1020 | ||