Vitamin D and female fertility
Purpose of review - Apart from the well known effects of vitamin D on maintaining calcium homeostasis and promoting bone mineralization, there is some evidence suggesting that vitamin D also modulates human reproductive processes. We will review the most interesting and relevant studies on vitamin...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2014
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| In: |
Current opinion in obstetrics and gynecology
Year: 2014, Volume: 26, Issue: 3, Pages: 145-150 |
| ISSN: | 1473-656X |
| DOI: | 10.1097/GCO.0000000000000065 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/GCO.0000000000000065 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/co-obgyn/Fulltext/2014/06000/Vitamin_D_and_female_fertility.5.aspx 
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| Author Notes: | Elisabeth Lerchbaum and Thomas Rabe |
MARC
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| 520 | |a Purpose of review - Apart from the well known effects of vitamin D on maintaining calcium homeostasis and promoting bone mineralization, there is some evidence suggesting that vitamin D also modulates human reproductive processes. We will review the most interesting and relevant studies on vitamin D and female fertility published over the past year. - Recent findings - In the past year, several observational studies reported a better in-vitro fertilization outcome in women with sufficient vitamin D levels (≥30 ng/ml), which was mainly attributed to vitamin D effects on the endometrium. One randomized controlled trial found an increased endometrial thickness in women with polycystic ovary syndrome (PCOS) receiving vitamin D during intrauterine insemination cycles. Further, vitamin D supplementation had a beneficial effect on serum lipids in PCOS women. Vitamin D treatment improved endometriosis in a rat model and increased vitamin D intake was related to a decreased risk of incident endometriosis. Vitamin D was also favorably associated with primary dysmenorrhea, uterine leiomyoma, and ovarian reserve in late reproductive aged women. - Summary - In women undergoing in-vitro fertilization, a sufficient vitamin D level (≥30 ng/ml) should be obtained. Vitamin D supplementation might improve metabolic parameters in women with PCOS. A high vitamin D intake might be protective against endometriosis. | ||
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