Indirect evidence for proton pump inhibitor failure in patients taking them independent of meals
Purpose: We investigated the association between conditions of proton pump inhibitor (PPI) treatment failure and food intake in an elderly ambulatory population. Methods: Our data originate from a large population-based cohort study. During a home visit done by a trained study physician, patients we...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 April 2014
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| In: |
Pharmacoepidemiology and drug safety
Year: 2014, Jahrgang: 23, Heft: 7, Pages: 768-772 |
| ISSN: | 1099-1557 |
| DOI: | 10.1002/pds.3620 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1002/pds.3620 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1002/pds.3620 
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| Verfasserangaben: | Julia Freigofas, Walter E. Haefeli, Ben Schöttker, Hermann Brenner, Renate Quinzler |
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| 245 | 1 | 0 | |a Indirect evidence for proton pump inhibitor failure in patients taking them independent of meals |c Julia Freigofas, Walter E. Haefeli, Ben Schöttker, Hermann Brenner, Renate Quinzler |
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| 520 | |a Purpose: We investigated the association between conditions of proton pump inhibitor (PPI) treatment failure and food intake in an elderly ambulatory population. Methods: Our data originate from a large population-based cohort study. During a home visit done by a trained study physician, patients were asked for each medication to state whether it was taken in relation to a meal (before, concurrently with, and after) or independent of a meal. This information was analyzed for all patients taking a PPI daily and correlated to markers of PPI failure. Results: Out of 2717 patients participating in a home visit and taking at least one medication, 383 took a PPI daily (14.1%). A PPI intake independent of meals was defined as incorrect and was observed in 64 patients, whereas 319 patients took their PPI in relation to a meal, which was defined as the correct intake. Treatment failure was observed in 10 out of 64 (15.6%) PPI users with incorrect intake and in 18 out of 319 (5.6%) PPI users with correct intake. The risk of treatment failure was threefold higher in patients taking their PPI independent of meals (OR 3.35; 95%CI 1.44-7.76). Conclusion: The higher risk for PPI failure in patients taking PPIs independent of meals suggests that synchronized PPI administration with meals is indeed essential, and better counseling of patients is needed. | ||
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