TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas
Acyl-CoA synthetase 5 (ACSL5), a mitochondrially localized enzyme, catalyzes the synthesis of long-chain fatty acid thioesters and is physiologically involved in pro-apoptotic sensing of enterocytes. The aim of the present study is to identify an ACSL5-dependent regulation of mitochondrially express...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 April 2014
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| In: |
Cell & tissue research
Year: 2014, Jahrgang: 357, Heft: 1, Pages: 267-278 |
| ISSN: | 1432-0878 |
| DOI: | 10.1007/s00441-014-1826-8 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00441-014-1826-8
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| Verfasserangaben: | Christina Klaus, Elke Kaemmerer, Andrea Reinartz, Ursula Schneider, Patrick Plum, Min Kyung Jeon, Josephine Hose, Franziska Hartmann, Martina Schnölzer, Norbert Wagner, Jürgen Kopitz, Nikolaus Gassler |
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Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis
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