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TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas

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Acyl-CoA synthetase 5 (ACSL5), a mitochondrially localized enzyme, catalyzes the synthesis of long-chain fatty acid thioesters and is physiologically involved in pro-apoptotic sensing of enterocytes. The aim of the present study is to identify an ACSL5-dependent regulation of mitochondrially express...

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Main Authors: Klaus, Christina (Author) , Schnölzer, Martina (Author) , Kopitz, Jürgen (Author)
Format: Article (Journal)
Language:English
Published: 29 April 2014
In: Cell & tissue research
Year: 2014, Volume: 357, Issue: 1, Pages: 267-278
ISSN:1432-0878
DOI:10.1007/s00441-014-1826-8
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00441-014-1826-8
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Author Notes:Christina Klaus, Elke Kaemmerer, Andrea Reinartz, Ursula Schneider, Patrick Plum, Min Kyung Jeon, Josephine Hose, Franziska Hartmann, Martina Schnölzer, Norbert Wagner, Jürgen Kopitz, Nikolaus Gassler
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Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis by Reinartz, Andrea (Author) , Ehling, Josef (Author) , Leue, Andrea (Author) , Liedtke, Christian (Author) , Schneider, Ursula (Author) , Kopitz, Jürgen (Author) , Weiss, Thomas (Author) , Hellerbrand, Claus (Author) , Weiskirchen, Ralf (Author) , Knüchel, Ruth (Author) , Gassler, Nikolaus (Author) ,


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