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Microvascular mural cell organotypic heterogeneity and functional plasticity

Microvascular mural cells (MMCs), comprising pericytes and microvascular smooth muscle cells, are of increasing interest in multiple fields of research for their plasticity and their organotypic functional roles in microvascular homeostasis and disease. They have been described as a heterogeneous ce...

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Hauptverfasser: Holm, Annegret Elisabeth (VerfasserIn) , Heumann, Tina (VerfasserIn) , Augustin, Hellmut (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 2018
In: Trends in cell biology
Year: 2018, Jahrgang: 28, Heft: 4, Pages: 302-316
ISSN:1879-3088
DOI:10.1016/j.tcb.2017.12.002
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tcb.2017.12.002
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0962892417302350
Volltext
Verfasserangaben:Annegret Holm, Tina Heumann, and Hellmut G. Augustin

MARC

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520 |a Microvascular mural cells (MMCs), comprising pericytes and microvascular smooth muscle cells, are of increasing interest in multiple fields of research for their plasticity and their organotypic functional roles in microvascular homeostasis and disease. They have been described as a heterogeneous cell population constituting a continuum of cell phenotypes along the microvascular bed with vascular smooth muscle cells (VSMCs) at one end of the spectrum and pericytes at the other end. MMC organotypic subpopulations have been suggested to function in a tissue-context-dependent manner, thereby contributing to organ-specific functional roles. However, the phenotypic and organotypic heterogeneity as well as their origin and marker identification are hitherto poorly defined. Here we review recent work and emerging concepts regarding MMC phenotypic and organotypic heterogeneity and their functional plasticity in health and disease. 
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