MD simulations of the central pore of ryanodine receptors and sequence comparison with 2B protein from coxsackie virus
The regulation of intracellular Ca2+ triggers a multitude of vital processes in biological cells. Ca2+ permeable ryanodine receptors (RyRs) are the biggest known ion channels and play a key role in the regulation of intracellular calcium concentrations, particularly in muscle cells. In this study, w...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2014
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| In: |
Biochimica et biophysica acta. Biomembranes
Year: 2013, Jahrgang: 1838, Heft: 4, Pages: 1122-1131 |
| ISSN: | 1879-2642 |
| DOI: | 10.1016/j.bbamem.2013.12.008 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bbamem.2013.12.008 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0005273613004471 
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| Verfasserangaben: | Roman Schilling, Rainer H.A. Fink, Wolfgang B. Fischer |
MARC
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| 520 | |a The regulation of intracellular Ca2+ triggers a multitude of vital processes in biological cells. Ca2+ permeable ryanodine receptors (RyRs) are the biggest known ion channels and play a key role in the regulation of intracellular calcium concentrations, particularly in muscle cells. In this study, we construct a computational model of the pore region of the skeletal RyR and perform molecular dynamics (MD) simulations. | ||
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